Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.
Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.
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DOI：
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发表时间：
2011
影响因子：
5.3
通讯作者：
S. Bellanger;Chye Ling Tan;Yuezhen Xue;S. Teissier;F. Thierry
中科院分区：
文献类型：
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作者：
S. Bellanger;Chye Ling Tan;Yuezhen Xue;S. Teissier;F. Thierry
乳头瘤病毒 (PV) E2 蛋白已被证明在病毒周期中发挥许多功能，包括在转录调节和病毒 DNA 复制中发挥关键作用。除了这些依赖于与特定 DNA 序列结合的能力的历史作用之外，E2 还被证明可以通过直接的蛋白质相互作用（主要是通过其氨基末端反式激活结构域）来调节宿主细胞。我们将在此描述 E2 的一些新功能及其在 HPV 诱导的癌发生中的潜在意义。更具体地说，我们将重点关注 E2 介导的宿主细胞周期调节及其对细胞转化的影响。总之，HPV E2 蛋白表现出独立于转录的复杂功能，可以与病毒营养周期一致地调节宿主细胞，并可能参与早期癌变。
The papillomavirus (PV) E2 proteins have been shown to exert many functions in the viral cycle including pivotal roles in transcriptional regulation and in viral DNA replication. Besides these historical roles, which rely on their aptitude to bind to specific DNA sequences, E2 has also been shown to modulate the host cells through direct protein interactions mainly through its amino terminal transactivation domain. We will describe here some of these new functions of E2 and their potential implication in the HPV-induced carcinogenesis. More particularly we will focus on E2-mediated modulation of the host cell cycle and consequences to cell transformation. In all, the HPV E2 proteins exhibit complex functions independent of transcription that can modulate the host cells in concert with the viral vegetative cycle and which could be involved in early carcinogenesis.