Risk of pancreatic adenocarcinoma - Disparity between African Americans and other race/ethnic groups
Risk of pancreatic adenocarcinoma - Disparity between African Americans and other race/ethnic groups
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DOI：
10.1002/cncr.20771
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发表时间：
2005-01-15
期刊：
影响因子：
6.2
通讯作者：
Anton-Culver, H
中科院分区：
文献类型：
--
作者：
Chang, KJ;Parasher, G;Anton-Culver, H
背景资料。与非西班牙裔白人相比，非裔美国人患胰腺癌的几率更高。这两组患者之间是否存在其他临床差异尚不清楚。方法：作者对1988-1998年间地区和全州范围内的所有胰腺癌患者进行了基于人群的回顾性分析。他们的目标是评估不同种族/民族在发病率、临床表现(包括确诊时的年龄、性别和肿瘤特征)和治疗方面的差异。结果：非洲裔美国人的年龄调整后胰腺癌发病率(8.78)高于非西班牙裔白人(5.89)、西班牙裔(5.09)、亚洲人(4.75)以及所有种族/民族的总和(5.82)。非洲裔美国人也出现在疾病的后期，接受的手术比所有其他种族/民族都少，尽管医疗保险是平等的。分析还揭示了性别差异。总体而言，在所有种族/民族中，男性胰腺癌的发病率都高于女性。在所有种族/族裔群体中，女性被确诊的年龄都比男性更大，疾病阶段也比男性更早。在考虑分期和治疗后，60岁女性的比例风险死亡率显著低于同龄男性(P<；0.02)。结论：在加利福尼亚州，非裔美国人的胰腺癌发病率较高，罹患晚期疾病和不可切除肿瘤(即位于胰腺身体或尾部的肿瘤)的风险略高，与所有其他种族/民族相比，接受的手术治疗较少。所有种族/民族的年轻女性都比同龄男性有生存优势。(C)2004年美国癌症协会。
BACKGROUND. African Americans have a higher incidence of pancreatic adenocarcinoma compared with non-Hispanic whites. Whether other clinical differences exist between these two groups is not well known.METHODS. The authors conducted a population-based retrospective analysis of all patients with pancreatic adenocarcinoma in both a regional and a statewide database between 1988 and 1998. Their goal was to evaluate differences in incidence rates, clinical presentation, including age at diagnosis, gender, and tumor characteristics, and treatment among race/ethnic groups.RESULTS. African Americans had a higher age-adjusted incidence rate of pancreatic adenocarcinoma (8.78) compared with non-Hispanic whites (5.89), Hispanics (5.09), Asians (4.75), and all race/ethnicities combined (5.82). African Americans also presented at a later stage of disease and received less surgery than all other race/ethnicities, despite equal availability of medical insurance. The analyses also revealed gender differences. In general, males maintained a higher incidence rate of pancreatic adenocarcinoma than females across all race/ethnicities. In all race/ethnic groups, females were diagnosed at an older age and an earlier stage of disease than males. The proportional hazard mortality ratio for females age < 60 was significantly less than that for males in the same age group (P < 0.02), even after accounting for stage and treatment.CONCLUSIONS. African Americans in California had a higher incidence rate of pancreatic adenocarcinoma, had a slightly higher risk of presenting with advanced-stage diseas and with nonresectable tumors (i.e., tumors located in the body or tail of the pancreas), and underwent less surgical treatment than all other race/ethnicities. Younger females in all race/ethnic groups had a survival advantage over males of the same age. (C) 2004 American Cancer Society.