Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women
Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women
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DOI：
10.1053/meta.2000.17672
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发表时间：
2000-11-01
影响因子：
9.8
通讯作者：
Hill, JO
中科院分区：
文献类型：
--
作者：
Cordain, L;Melby, CL;Hill, JO
流行病学研究表明，饮酒与胰岛素敏感性的改善有关;然而，很少有实验证据证实这一观察结果。为了确定定期适度饮酒对胰岛素敏感性的影响，20名超重女性（体重指数[BMI]，29.8 +/- 2.2 kg/m2）参加了一项为期20周的自由生活随机交叉试验。受试者，作为他们自己的控制，消费葡萄酒（190吨红葡萄酒，13%体积/体积乙醇，每周5天）10周，并禁欲10周，反之亦然。在预试验、10周交叉和20周研究完成时测量因变量（体重、BMO、体脂百分比、血压、空腹血糖和胰岛素、血脂、饮食摄入量和静脉葡萄糖耐量试验[IVGTT]的胰岛素敏感性）。在预测试时和研究的葡萄酒饮用和预防期完成时，使用ANOVA按处理顺序分析数据。空腹血糖保持不变（平均值+/- SD; P > 0.05）在整个实验过程中（试验前、饮酒和禁食，91.1 +/- 9.2、91.6 +/- 9.1和88.5 +/- 11.2 mg/dL），胰岛素敏感性、空腹胰岛素（试验前、饮酒和禁食，8.6 ± 3.3、8.6 ± 4.1和9.1 ± 4.7 μ U/mg）和胰岛素敏感性指数（3.60 ± 2.96、3.25 ± 2.17和3.30 ± 1.84）。体成分和血脂在治疗期间也保持不变（P > 0.05）。在超重女性中，适量饮用此剂量的葡萄酒不会改善或损害胰岛素敏感性，也不会改变任何已知的胰岛素敏感性相关因素，包括体重和成分，血脂和血压。Copyright（C）2000 by W.B.桑德斯公司
Epidemiologic studies indicate that alcohol consumption is associated with improved insulin sensitivity; however, scant experimental evidence confirms this observation. To determine the effects of regular moderate wine consumption on insulin sensitivity, 20 overweight women (body mass index [BMI], 29.8 +/- 2.2 kg/m(2)) participated in a 20-week free-living randomized crossover trial. The subjects, serving as their own controls, consumed wine (190 mt red wine, 13% vol/vol ethanol, 5 days per week) for 10 weeks and abstained for 10 weeks or vice versa. The dependent variables (body weight, BMO, percent body fat, blood pressure, fasting blood glucose and insulin, blood lipids, dietary intake, and insulin sensitivity by intravenous glucose tolerance test [IVGTT]) were measured at the pretest, at the 10-week crossover, and at the 20-week completion of the study. Data were analyzed at the pretest and at completion of the wine drinking and abstention periods of the study using ANOVA by order of treatment. Fasting glucose remained unchanged (mean +/- SD; P > .05) throughout the experiment (pretest, drinking, and abstention, 91.1 +/- 9.2, 91.6 +/- 9.1, and 88.5 +/- 11.2 mg/dL), as did the measures of insulin sensitivity, fasting insulin (pretest, drinking, and abstention, 8.6 +/- 3.3, 8.6 +/- 4.1, and 9.1 +/- 4.7 muU/mg) and the insulin sensitivity index (3.60 +/- 2.96, 3.25 +/- 2.17, and 3.30 +/- 1.84). Body composition and blood lipids also remained unchanged (P > .05) during treatment. Moderate wine consumption at this dose in overweight women did not improve or impair insulin sensitivity, nor did it change any of the known correlates of insulin sensitivity, including body weight and composition, blood lipids, and blood pressure. Copyright (C) 2000 by W.B. Saunders Company.