THE DIAGNOSIS OF OVARIAN-CANCER BY PATHOLOGISTS - HOW OFTEN DO DIAGNOSES BY CONTRIBUTING PATHOLOGISTS AGREE WITH A PANEL OF GYNECOLOGIC PATHOLOGISTS
THE DIAGNOSIS OF OVARIAN-CANCER BY PATHOLOGISTS - HOW OFTEN DO DIAGNOSES BY CONTRIBUTING PATHOLOGISTS AGREE WITH A PANEL OF GYNECOLOGIC PATHOLOGISTS
复制标题
DOI：
10.1016/0002-9378(91)90628-5
复制
发表时间：
1991-01-01
影响因子：
9.8
通讯作者：
WILLIAMSON, GD
中科院分区：
文献类型：
--
作者：
TYLER, CW;LEE, NC;WILLIAMSON, GD
癌症和类固醇激素研究是一项针对 20 至 54 岁女性卵巢癌、乳腺癌和子宫内膜癌的多中心、基于人群的病例对照研究，允许将贡献的病理学家的诊断与由三名妇科病理学家组成的小组的诊断进行比较。病理学家对 477 名受试者进行了卵巢癌诊断。两组病理学家对于原发性上皮性卵巢癌的一致性为 97%，对于原发性非上皮性卵巢恶性肿瘤的一致性为 89%。卵巢恶性肿瘤主要细胞亚型的诊断一致性在子宫内膜样癌的 73% 和透明细胞癌的 100% 之间。我们的结论是，原发性卵巢癌病理特征的诊断是高度可预测的。尽管如此，组织学类型的诊断差异很大，因此涉及卵巢癌特定组织学诊断的临床或研究决策应考虑审查过程。
The Cancer and Steroid Hormone Study, a multicenter, population-based, case-control study of ovarian, breast, and endometrial cancer in women 20 to 54 years of age, permitted the diagnoses of contributing pathologists to be compared with those of a panel of three gynecologic pathologists. A diagnosis of ovarian cancer was made by contributing pathologists on 477 subjects. Agreement between the two groups of pathologists was 97% for primary epithelial ovarian cancer and 89% for primary nonepithelial ovarian malignancies. Agreement on diagnosis of major cellular subtypes of ovarian malignancy ranged between 73% for endometrioid cancer and 100% for clear cell carcinomas. We conclude that the diagnosis of pathologic features of primary ovarian cancer is highly predictable. Nonetheless, diagnosis by histologic type varies sufficiently that a review process should be considered for clinical or investigative decisions involving specific histologic diagnoses of ovarian cancer.