The disruption of prepulse inhibition by social isolation in the Wistar rat: How robust is the effect?
The disruption of prepulse inhibition by social isolation in the Wistar rat: How robust is the effect?
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DOI：
10.1016/s0091-3057(97)00534-0
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发表时间：
1998-04-01
影响因子：
3.6
通讯作者：
Feldon, J
中科院分区：
文献类型：
--
作者：
Domeney, A;Feldon, J
研究表明，断奶后隔离饲养的大鼠会对多种行为的表达产生影响。目前的研究调查了 Wistar 大鼠品系中隔离诱导的前脉冲抑制（PPI）反应的破坏，作为动物暴露于运动活动测试的函数。此外，还对 PPI 进行了重复测试，以检查隔离引起的干扰的稳健性。结果表明，实验中首次隔离饲养的动物表现出 PPI 反应的破坏，这种破坏在 7 天后的第二次测试中得以保留。结果表明，所获得的干扰在所有检查的脉冲频率上都是一致的，并且与惊吓的影响无关。然而，无论是在测量 PPI 之前还是之后进行活动测试，都消除了后续测试中隔离引起的 PPI 中断。相比之下，运动活动测试始终显示隔离饲养的动物存在过度活跃反应，且不受测试时间发生的影响。研究结果的讨论涉及对在同一动物中进行活动测试和 PPI 的研究中出现的数据的解释，以及与在隔离饲养的动物中使用 PPI 作为代表精神分裂症的非药理学动物模型的关系。 (C) 1998 爱思唯尔科学公司。
Postweaning isolation rearing in rats is shown to have consequences for the expression of numerous behaviors. The present studies investigated isolation-induced disruptions of the prepulse inhibition (PPI) response in the Wistar rat strain, as a function of exposure of the animals to locomotor activity testing. Further, repeated testing of PPI was investigated to examine the robustness of the isolation-induced disruptions. The results indicate that experimentally naive isolation-reared animals exhibit disruptions in the PPI response that are retained in a second test 7 days later. The disruptions obtained are shown to be consistent across all pulse frequencies examined and independent of effects on startle. Exposure to activity testing, however, either before or after the measurement of PPI, abolished the isolation-induced disruption of PPI in a subsequent test. In contrast, locomotor activity testing consistently revealed a hyperactivity response in isolation-reared animals that was not influenced by the temporal occurrence of the testing. The findings are discussed relative to the interpretation of data emerging from studies where both activity testing and PPI are performed in the same animals, and in the relation to the use of PPI in isolation-reared animals as representing a nonpharmacological animal model of schizophrenia. (C) 1998 Elsevier Science Inc.