The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity.
The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity.
复制标题
DOI：
10.1038/nn.4056
复制
发表时间：
2015-08
影响因子：
25
通讯作者：
Leutgeb S
中科院分区：
文献类型：
--
作者：
Schlesiger MI;Cannova CC;Boublil BL;Hales JB;Mankin EA;Brandon MP;Leutgeb JK;Leibold C;Leutgeb S
内侧内嗅皮层 (MEC) 的浅层是海马体的主要输入。这些层中空间调制细胞（包括网格细胞和边界细胞）比例较高，表明海马体的 MEC 输入对于海马体空间的表征至关重要。然而，MEC 的选择性操作并不能完全消除海马空间放电。因此，为了确定其他海马放电特征是否更关键地依赖于 MEC 输入，我们记录了 MEC 损伤大鼠的海马 CA1 细胞。引人注目的是，即使在稳定的空间发射期间，θ 相进动也被严重破坏。我们的研究结果表明，海马放电模式的时间组织需要 MEC 输入到海马，并表明依赖于海马 θ 周期内精确神经元序列的认知功能特别依赖于 MEC。
The superficial layers of the medial entorhinal cortex (MEC) are the major input to the hippocampus. The high proportion of spatially modulated cells, including grid cells and border cells, in these layers suggests that the MEC inputs to the hippocampus are critical for the representation of space in the hippocampus. However, selective manipulations of the MEC do not completely abolish hippocampal spatial firing. To therefore determine whether other hippocampal firing characteristics depend more critically on MEC inputs, we recorded from hippocampal CA1 cells in rats with MEC lesions. Strikingly, theta phase precession was substantially disrupted, even during periods of stable spatial firing. Our findings indicate that MEC inputs to the hippocampus are required for the temporal organization of hippocampal firing patterns and suggest that cognitive functions that depend on precise neuronal sequences within the hippocampal theta cycle are particularly dependent on the MEC.