Low Wall Shear Stress Is Independently Associated With the Rupture Status of Middle Cerebral Artery Aneurysms
Low Wall Shear Stress Is Independently Associated With the Rupture Status of Middle Cerebral Artery Aneurysms
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DOI：
10.1161/strokeaha.112.675306
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发表时间：
2013-02-01
期刊：
影响因子：
8.3
通讯作者：
Taki, Waro
中科院分区：
文献类型：
--
作者：
Miura, Yoichi;Ishida, Fujimaro;Taki, Waro
背景和目的-我们确定的血流动力学参数独立的特点破裂状态的大脑中动脉（MCA）动脉瘤using computational fluid dynamics analysis. Methods-在106例患者的具体几何形状的大脑中动脉瘤（43破裂，63未破裂），形态和血流动力学参数之间进行了比较破裂和未破裂组。进行多变量Logistic回归分析，以确定参数，独立的特点MCA aneurysms.Results-Univariate分析的破裂状态显示，纵横比，壁面切应力（WSS），归一化WSS，振荡剪切指数，WSS梯度，和血管形成指数是显着的参数。两组之间的前庭圆顶大小和梯度振荡数无显著差异。多因素分析显示，只有较低的WSS与MCA动脉瘤破裂状态显著相关。结论WSS可能是表征MCA动脉瘤破裂状态的最可靠参数。（中风。2013;44：519-521）。
Background and Purpose-We determined which hemodynamic parameter independently characterizes the rupture status of middle cerebral artery (MCA) aneurysms using computational fluid dynamics analysis.Methods-In 106 patient-specific geometries of MCA aneurysms (43 ruptured, 63 unruptured), morphological and hemodynamic parameters were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine parameters that independently characterized the rupture status of MCA aneurysms.Results-Univariate analyses showed that the aspect ratio, wall shear stress (WSS), normalized WSS, oscillatory shear index, WSS gradient, and aneurysm-formation index were significant parameters. The size of the aneurysmal dome and the gradient oscillatory number were not significantly different between the 2 groups. With multivariate analyses, only lower WSS was significantly associated with the rupture status of MCA aneurysms.Conclusions-WSS may be the most reliable parameter characterizing the rupture status of MCA aneurysms. (Stroke. 2013;44:519-521.)