Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging.
Targeting activated hepatic stellate cells (aHSCs) for liver fibrosis imaging.
复制标题
靶向激活的肝星状细胞 (aHSC) 进行肝纤维化成像
DOI：
10.1186/s13550-015-0151-x
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发表时间：
2015-12
期刊：
影响因子：
3.2
通讯作者：
Shan H
中科院分区：
文献类型：
--
作者：
Li D;He L;Guo H;Chen H;Shan H
在受到损伤刺激后，静止的肝星状细胞（qhsc）可转分化为活化的肝星状细胞（aHSCs）。aHSCs在肝纤维化的发生和发展中起关键作用。因此，肝纤维化中aHSCs的分子成像将有助于早期诊断、预后预测以及指导和评估ahsc靶向治疗。到目前为止，一些受体，如整合素αvβ3，甘糖6-磷酸/胰岛素样生长因子II受体（M6P/IGF-IIR），胶原型VI受体（CVIR），血小板衍生生长因子受体-β (PDGFR-β)， vimentin和desmin，已被确定为ahsc的生物标志物。与这些受体相对应的配体也已被开发出来。本文将讨论在肝纤维化中发展ahsc靶向成像的策略。
Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver fibrosis. Therefore, molecular imaging of aHSCs in liver fibrosis will facilitate early diagnosis, prognosis prediction, and instruction and evaluation of aHSC-targeted treatment. To date, several receptors, such as integrin αvβ3, mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF-IIR), collagen type VI receptor (CVIR), platelet-derived growth factor receptor-β (PDGFR-β), vimentin, and desmin, have been identified as biomarkers of aHSCs. Corresponding ligands to these receptors have also been developed. This review will discuss strategies for developing aHSC-targeted imaging in liver fibrosis.