Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome
Global genome analysis reveals a vast and dynamic anellovirus landscape within the human virome
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DOI：
10.1016/j.chom.2021.07.001
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发表时间：
2021-08-11
影响因子：
30.3
通讯作者：
Yozwiak, Nathan L.
中科院分区：
文献类型：
--
作者：
Arze, Cesar A.;Springer, Simeon;Yozwiak, Nathan L.
环节病毒是健康人类病毒组的普遍存在的组分，并且在生命早期获得后保持高度流行。“anellome”多样性的全部范围及其进化动力学仍然未被探索。我们对输血供体-受体对进行了深入测序，并结合公共基因组资源进行了大规模的环节病毒基因组组装，并使用这些数据来表征全球和个人环节病毒的多样性。anellome的宽度比以前认识到的要大得多，并且个体具有独特的anellomes并传输可以在地方性宿主谱系的不同环境中持续数月的谱系。环节病毒的序列多样性是由广泛的重组在所有水平的分歧，阻碍了传统的系统发育分析。我们的研究结果阐明了环节病毒的传播动力学和多样性，并为未来研究其生物学特性奠定了基础。
Anelloviruses are a ubiquitous component of healthy human viromes and remain highly prevalent after being acquired early in life. The full extent of "anellome" diversity and its evolutionary dynamics remain unexplored. We employed in-depth sequencing of blood-transfusion donor(s)-recipient pairs coupled with public genomic resources for a large-scale assembly of anellovirus genomes and used the data to characterize global and personal anellovirus diversity through time. The breadth of the anellome is much greater than previously appreciated, and individuals harbor unique anellomes and transmit lineages that can persist for several months within a diverse milieu of endemic host lineages. Anellovirus sequence diversity is shaped by extensive recombination at all levels of divergence, hindering traditional phylogenetic analyses. Our findings illuminate the transmission dynamics and vast diversity of anelloviruses and set the foundation for future studies to characterize their biology.