The Emerging Role of Irisin in Cardiovascular Diseases
The Emerging Role of Irisin in Cardiovascular Diseases
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DOI：
10.1161/jaha.121.022453
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发表时间：
2021
影响因子：
5.4
通讯作者：
Jian Yang
中科院分区：
文献类型：
--
作者：
Jinjuan Fu;Fangtang Li;Yuanjuan Tang;Lin Cai;Chunyu zeng;Yongjian Yang;Jian Yang
Irisin, a novel hormone like polypeptide, is cleaved and secreted by an unknown protease from a membrane spanning protein, FNDC5 (fibronectin type III domain-containing protein 5). The current knowledge on the biological functions of irisin includes browning white adipose tissue, regulating insulin use, and anti-inflammatory and antioxidative properties. Dysfunction of irisin has shown to be involved in cardiovascular diseases such as hypertension, coronary artery disease, myocardial infarction, and myocardial ischemia–reperfusion injury. Moreover, irisin gene variants are also associated with cardiovascular diseases. In this review, we discuss the current knowledge on irisin-mediated regulatory mechanisms and their roles in the pathogenesis of cardiovascular diseases.
