Periodontal Host Response in Subjects with Obesity
Periodontal Host Response in Subjects with Obesity
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DOI：
10.1007/s40496-018-0177-z
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发表时间：
2018-04
影响因子：
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通讯作者：
H. Hayashida;R. Furugen;Toshiyuki Saito
中科院分区：
文献类型：
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作者：
H. Hayashida;R. Furugen;Toshiyuki Saito
目的ReviewThis审查的重点是在了解牙周宿主反应在肥胖subjects.Recent FindingsIncreased促炎脂肪因子，如瘦素，颗粒蛋白原，β-淀粉样蛋白，visfatin和减少抗炎脂肪因子，如脂联素，加剧炎症反应，牙槽骨吸收，并抑制组织再生的最新进展已被观察到在牙周组织中肥胖subjects。氧化应激的升高也会影响牙周炎的进展。肥胖可能会影响microRNAs的表达相关的炎症和代谢mRNA的目标在牙周tissue.SummaryAlthough肥胖可能会促进牙周炎的进展，在多种方式，需要进一步的研究，以澄清在肥胖的牙周宿主反应。
Purpose of ReviewThis review focuses on recent advances in understanding the periodontal host response in obese subjects.Recent FindingsIncreased pro-inflammatory adipokines such as leptin, progranulin, resistin, and visfatin and decreased anti-inflammatory adipokines such as adiponectin, exacerbated inflammatory response, alveolar bone resorption, and inhibition of tissue regeneration have been observed in the periodontal tissue in obese subjects. Elevated oxidative stress also affects progression of periodontitis. Obesity may affect the expression of microRNAs related to inflammatory and metabolic mRNA targets in periodontal tissue.SummaryAlthough obesity may promote the progression of periodontitis in multiple manners, additional studies are needed to clarify the periodontal host response in obesity.