Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas
Overexpression of EGFR and absence of C-KIT expression correlate with poor prognosis in salivary gland carcinomas
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DOI：
10.1111/j.1365-2559.2008.03159.x
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发表时间：
2008-11-01
期刊：
影响因子：
6.4
通讯作者：
Driemel, O.
中科院分区：
文献类型：
--
作者：
Ettl, T.;Schwarz, S.;Driemel, O.
目标：为了评估受体酪氨酸激酶表皮生长因子受体（EGFR），HER 2，和C-KIT的表达与建立的临床病理参数在涎腺carcinoma.Methods和结果的预后影响：免疫组化EGFR，HER 2，C-KIT和增殖标志物Ki 67进行了101例涎腺癌和相关的长期临床随访。C-KIT在腺样囊性癌中的阳性率为92%。C-KIT在涎腺导管癌中表达缺失（P < 0.001），与肿瘤高级别（P = 0.002）、淋巴结阳性（P = 0.002）和Ki 67高表达（P = 0.001）有关。HER 2通常在涎腺导管癌中表达（83%），但与任何其他参数无关。EGFR过度表达发生独立的组织学类型和临床参数。在单因素生存分析中，EGFR过表达（P = 0.011）和C-KIT缺乏（P = 0.014）与预后不良相关，而HER 2无预后意义。在多变量分析中，生存率最强的阴性预测因子是Ki 67测定的高增殖活性（P = 0.002），其次是存在残留肿瘤（P = 0.006），EGFR过表达结论：受体酪氨酸激酶的表达对疾病特异性生存率有额外的预后影响。EGFR过表达是一个独立的负性预后因素。
Aims: To evaluate the prognostic impact of expression of receptor tyrosine kinases epidermal growth factor receptor (EGFR), HER2, and C-KIT in relation to established clinicopathological parameters in salivary gland carcinomas.Methods and results: Immunohistochemistry for EGFR, HER2, C-KIT and the proliferation marker Ki67 was performed in 101 cases of salivary gland carcinoma and related to long-term clinical follow-up. Immunopositivity of C-KIT was common in adenoid cystic carcinoma (92%). Lack of C-KIT expression occurred in salivary duct carcinoma (P < 0.001) and was associated with high-grade tumours (P = 0.002), positive lymph nodes (P = 0.002) and high expression of Ki67 (P = 0.001). HER2 was typically expressed in salivary duct carcinomas (83%), but was not associated with any other parameter. EGFR overexpression occurred independently of histological type and clinical parameters. On univariate survival analysis, overexpression of EGFR (P = 0.011) and lack of C-KIT (P = 0.014) were associated with worse prognosis, whereas HER2 was of no prognostic significance. On multivariate analysis, the strongest negative predictor of survival was high proliferative activity measured by Ki67 (P = 0.002), followed by presence of residual tumour (P = 0.006), overexpression of EGFR (P = 0.026) and advanced tumour stage (P = 0.041).Conclusions: The expression of receptor tyrosine kinases confers additional prognostic impact on disease-specific survival. EGFR overexpression is an independent negative prognostic factor.