Histological phases of Bactrim-induced fixed drug eruption. The report of one case.
Histological phases of Bactrim-induced fixed drug eruption. The report of one case.
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Bactrim 诱导的固定性药疹的组织学阶段。
DOI：
10.1097/00000372-198712000-00010
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发表时间：
1987
影响因子：
1.1
通讯作者：
Kurt S. Stenn
中科院分区：
文献类型：
--
作者：
Abby Van Voorhees;Kurt S. Stenn
一个案例是描述与百菌清引起的固定药疹（FDE）的患者。在药物暴露后1天和5天进行组织学研究。虽然5日龄病变显示出典型的FDE变化，但1日龄病变显示出典型的超敏反应变化：弥漫性海绵状组织增生、真皮水肿和出血、嗜酸性多形核白细胞脓肿形成和大量嗜酸性粒细胞。这份报告强调了动态细胞的变化，发生在不断发展的FDE病变。
A case is described of a patient with Bactrim-induced fixed drug eruption (FDE). Histological studies were performed at 1 day and 5 days after the drug exposure. While the 5-day-old lesion showed changes classically recognized as FDE, the 1-day-old lesion showed changes typical of a hypersensitivity response: diffuse spongiosis, dermal edema and hemorrhage, neutrophilic polymorphonuclear leukocyte abscess formations, and large numbers of eosinophils. This report underscores the dynamic cellular changes that occur in the evolving FDE lesion.