Immunopathogenesis in Chlamydia trachomatis Infected Women.
Immunopathogenesis in Chlamydia trachomatis Infected Women.
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DOI：
10.5402/2011/436936
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Oliva, Alessandra
中科院分区：
文献类型：
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作者：
Mascellino, Maria Teresa;Boccia, Priscilla;Oliva, Alessandra
我们研究了沙眼衣原体（Ct）的免疫发病机制的基础上，宿主免疫反应和毒力微生物因子之间的复杂相互作用。Ct感染可以是无症状的，也可以是由再感染或持续感染引起的炎症。我们讨论了宿主的多态性，它们的抗炎或促炎作用，决定了疾病的进程。我们还考虑了衣原体疾病后的炎症过程以及产生IFN-γ的CD 4细胞和产生细胞因子的CD 8细胞的作用。考虑了Ct-hsp 60的关键作用和抗Ct-hsp 60抗体的双重活性（破坏或保留某些类型的肿瘤）。
We examine the Chlamydia trachomatis (Ct) immunopathogenesis on the basis of the complex interaction between host immune response and virulence microorganism factors. Ct infection can be asymptomatic or may produce an inflammation elicited and preserved by reinfections or persistent infections. We discuss the host polymorphisms that, with their anti- or proinflammatory effects, determine the course of the disease. We also took into account the inflammation process following the Chlamydia illness and the role of both CD4 cells producing IFN-gamma and CD8 cells with their cytokines production. The crucial role of Ct-hsp60 and the double activity (either damaging or preserving from some kinds of tumors) of anti-Ct-hsp60 antibodies are considered.