Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: Revisiting a meta-analysis of randomised trials
Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: Revisiting a meta-analysis of randomised trials
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DOI：
10.1016/s0959-8049(99)00076-3
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发表时间：
1999-07-01
影响因子：
8.4
通讯作者：
Maroun, JA
中科院分区：
文献类型：
--
作者：
Earle, CC;Maroun, JA
本研究的目的是评估胃癌根治性切除术后辅助化疗是否能提高生存率。数据来源：检索MEDLINE（1966-1999）、CancerLit（1983-1999）、参考文献、个人重印文件和综述文章以查找相关文章。研究必须是在非亚洲国家进行的胃癌根治性切除术后辅助化疗与观察的随机对照试验。两名评审员独立评价了试验的合格性、质量评估和数据提取。13项试验符合合格性标准。治疗组死亡的比值比为0.80（95%置信区间（CI）0.66-0.97），对应的相对风险为0.94（95% CI 0.89-1.00），亚组分析显示，当分析仅限于至少2/3患者患有淋巴结阳性疾病的试验时，效应幅度有更大的趋势。我们的研究结果表明，辅助化疗可能会产生一个边缘统计学意义的胃癌根治性切除患者的生存效益小。继续试验以发现和确认有效的辅助策略是必要的。(C)1999 Elsevier Science Ltd.保留所有权利。
The aim of this study was to assess whether adjuvant chemotherapy after curative resection of gastric cancer increases survival rates. Data sources: MEDLINE (1966-1999), CancerLit (1983-1999), bibliographies, personal reprint files, and review articles were searched for relevant articles. Studies had to be randomised controlled trials of adjuvant chemotherapy versus observation following curative resection of stomach cancer that took place in non-Asian countries. Two reviewers independently evaluated the trials for eligibility, quality assessment and data abstraction. 13 trials met the eligibility criteria. The odds ratio for death in the treated group was 0.80 (95% confidence interval (CI) 0.66-0.97), corresponding to a relative risk of 0.94 (95% CI 0.89-1.00), Subgroup analyses showed a trend towards a larger magnitude of the effect when analysis was restricted to trials in which at least 2/3 of patients had node-positive disease. Our results suggest that adjuvant chemotherapy may produce a small survival benefit of borderline statistical significance in patients with curatively resected gastric carcinoma. Continued trials to find and confirm an effective adjuvant strategy are warranted. (C) 1999 Elsevier Science Ltd. All rights reserved.