Mitigating Cutaneous Sensation Differences During tDCS: Comparing Sham Versus Low Intensity Control Conditions
Mitigating Cutaneous Sensation Differences During tDCS: Comparing Sham Versus Low Intensity Control Conditions
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DOI：
10.1016/j.brs.2014.09.015
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发表时间：
2014-11-01
影响因子：
7.7
通讯作者：
Mahoney, Caroline R.
中科院分区：
文献类型：
--
作者：
Brunye, Tad T.;Cantelon, Julie;Mahoney, Caroline R.
背景资料：直流电脑刺激过程中电极部位的皮肤感觉可能会在无意中影响受试者的主观体验和任务表现。目的：本研究评估了一种方法学变化的实用性，该方法替代了非常低强度的假刺激（0.5 mA）电流输送。我们使用4 × 1高清晰度环形电极经颅直流电（HD-tDCS）系统靶向左背外侧前额叶皮层（Brodmann's Area 9）在重复测量设计中比较了四种刺激条件：假2.0 mA和0.5 mA强度，与活动2.0 mA和0.5 mA强度。在刺激参与者进行了认知干扰任务，激活扣带-额叶-顶叶网络，并定期提供感知觉ratings.Results：我们证明了一个相对较低的强度控制条件衰减，否则大的差异，在感知觉之间的活动和假条件。至关重要的是，行为任务之间的差异保持两个积极的conditions.Conclusion：低强度控制刺激条件可能被证明是一个可行的方法替代传统的假技术中使用的重复测量设计，虽然重要的限制进行了讨论。爱思唯尔公司出版
Background: Cutaneous sensations at electrode sites during the administration of direct current brain stimulation may inadvertently influence participants' subjective experience and task performance.Objective: The present study evaluated the utility of a methodological variation that substitutes sham administration with very low intensity (0.5 mA) current delivery.Methods: We used a 4 x 1 high-definition ring electrode transcranial direct current (HD-tDCS) system to target the left dorsolateral prefrontal cortex (Brodmann's Area 9). Four stimulation conditions were compared in a repeated-measures design: sham 2.0 mA and 0.5 mA intensity, versus active 2.0 mA and 0.5 mA intensity. During stimulation participants performed a cognitive interference task that activates the cingulo-frontal-parietal network, and periodically provided perceived sensation ratings.Results: We demonstrate that a relatively low intensity control condition attenuates otherwise large differences in perceived sensation between active and sham conditions. Critically, behavioral task differences maintained between the two active conditions.Conclusion: A low intensity control stimulation condition may prove a viable methodological alternative to conventional sham techniques used in repeated-measures designs, though important limitations are discussed. Published by Elsevier Inc.