Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go.
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新发现的脑钾通道由鸟嘌呤核苷酸结合蛋白 Go 门控。
DOI：
10.1126/science.3144040
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Brown,AM
中科院分区：
文献类型：
--
作者：
VanDongen,AM;Codina,J;Olate,J;Mattera,R;Joho,R;Birnbaumer,L;Brown,AM
神经元中的钾通道通过鸟嘌呤核苷酸结合 (G) 蛋白与众多神经递质受体连接。在海马锥体神经元的无细胞膜斑块中测试了 Go（大脑中主要的 G 蛋白）刺激钾通道的能力。四种不同类型的钾通道原本处于静止状态，但被分离的脑 Go 和重组 Goα 激活。因此，大脑 Gocan 将不同的大脑钾通道与神经递质受体结合起来。
Potassium channels in neurons are linked by guanine nucleotide binding (G) proteins to numerous neurotransmitter receptors. The ability of Go, the predominant G protein in the brain, to stimulate potassium channels was tested in cell-free membrane patches of hippocampal pyramidal neurons. Four distinct types of potassium channels, which were otherwise quiescent, were activated by both isolated brain Goand recombinant Goα. Hence brain Gocan couple diverse brain potassium channels to neurotransmitter receptors.