Immune system dysregulation following short- vs long-duration spaceflight
Immune system dysregulation following short- vs long-duration spaceflight
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DOI：
10.3357/asem.2276.2008
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发表时间：
2008-09-01
影响因子：
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通讯作者：
Sams, Clarence F.
中科院分区：
文献类型：
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作者：
Crucian, Brian E.;Stowe, Raymond P.;Sams, Clarence F.
导言：免疫系统失调已被证明发生在航天飞行期间和紧接其后。如果在长时间飞行中持续存在，这种现象可能会对参与月球或火星任务的机组人员造成严重的健康风险。研究方法：对17名短期航天飞机机组人员和8名长期国际空间站（ISS）机组人员进行了全面的飞行后免疫评估。检测包括外周血白细胞亚群分析、早期T细胞活化潜力和细胞内/分泌细胞因子谱。结果：对于航天飞机机组人员来说，飞行后外周血白细胞亚群的分布发生了变化。早期T细胞活化升高飞行后，然而，T细胞亚群的百分比能够被刺激产生IL-2和IFN γ下降。T细胞刺激后分泌的IFN γ：IL-10的比率在着陆后下降，表明Th 2移位。对于国际空间站的机组人员，在着陆后也检测到外周白细胞分布的一些变化。与航天飞机机组人员相比，国际空间站机组人员在飞行后立即表现出早期T细胞活化潜力的统计学显着降低。能够产生IL-2的T细胞的百分比降低，但IFN γ百分比不变。在国际空间站机组人员中也观察到飞行后分泌的IFN γ：IL-10比率（Th 2移位）的降低。结论：这些数据表明，一致的外周表型变化和改变细胞因子的生产概况发生后，短期和长期的航天飞行，然而，功能性免疫失调可能会有所不同的使命的持续时间。此外，可检测到的Th 2细胞因子变化似乎与航天飞行有关。
Introduction: Immune system dysregulation has been demonstrated to occur during and immediately following spaceflight. If found to persist during lengthy flights, this phenomenon could be a serious health risk to crewmembers participating in lunar or Mars missions. Methods: A comprehensive postflight immune assessment was performed on 17 short-duration Space Shuttle crewmembers and 8 long-duration International Space Station (ISS) crewmembers. Testing consisted of peripheral leukocyte subset analysis, early T cell activation potential, and intracellular/secreted cytokine profiles. Results: For Shuttle crewmembers, the distribution of the peripheral leukocyte subsets was found to be altered postflight. Early T cell activation was elevated postflight; however, the percentage of T cell subsets capable of being stimulated to produce IL-2 and IFN gamma was decreased. The ratio of secreted IFN gamma:IL-10 following T cell stimulation declined after landing, indicating a Th2 shift. For the ISS crewmembers, some alterations in peripheral leukocyte distribution were also detected after landing. In contrast to Shuttle crewmembers, the ISS crewmembers demonstrated a statistically significant reduction in early T cell activation potential immediately postflight. The percentage of T cells capable of producing IL-2 was reduced, but IFN gamma percentages were unchanged. A reduction in the secreted IFNy:IL-10 ratio (Th2 shift) was also observed postflight in the ISS crewmembers. Conclusion: These data indicate that consistent peripheral phenotype changes and altered cytokine production profiles occur following spaceflight of both short and long duration; however, functional immune dysregulation may vary related to mission duration. In addition, a detectable Th2 cytokine shift appears to be associated with spaceflight.