Use of the tumour colony assay in the evaluation of patients with bladder cancer.
Use of the tumour colony assay in the evaluation of patients with bladder cancer.
复制标题
肿瘤集落测定在膀胱癌患者评估中的应用。
DOI：
10.1111/j.1464-410x.1983.tb03296.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
M. Soloway
中科院分区：
文献类型：
--
作者：
H. Niell;M. Soloway
在这项研究中，我们在肿瘤菌落测定中检测了来自膀胱穿刺的肿瘤标本产生簇/菌落形成的能力。在来自65名患者和15名对照受试者的114次膀胱冲洗中，我们发现从活检证实膀胱癌且未进行膀胱内化疗的患者中获得的膀胱冲洗中，群集和集落形成最高。生长速度极低，限制了目前形式的体外测定的有效性。这项研究表明，在该系统在监测膀胱移行细胞癌方面具有真正的价值之前，必须提高肿瘤菌落测定的生长速度。
In this study we examined the ability of tumour specimens derived from bladder barbotage to produce cluster/colony formation in a tumour colony assay. In 114 bladder washings from 65 patients and 15 control subjects, we found that cluster and colony formation was highest from bladder washings obtained from patients with biopsy proven bladder cancer who were not on intravesical chemotherapy. Growth rates were extremely low, restricting the usefulness of the in vitro assay in its present form. This study suggests that improvements in the growth rates in the tumour colony assay will be necessary before this system can have real value in monitoring transitional cell carcinoma of the bladder.