Widespread Tau-Specific CD4 T Cell Reactivity in the General Population
Widespread Tau-Specific CD4 T Cell Reactivity in the General Population
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DOI：
10.4049/jimmunol.1801506
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发表时间：
2019-07-01
影响因子：
4.4
通讯作者：
Sette, Alessandro
中科院分区：
文献类型：
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作者：
Arlehamn, Cecilia S. Lindestam;Pham, John;Sette, Alessandro
Tau蛋白在许多神经系统疾病中被发现聚集和过度磷酸化（p-tau），包括帕金森病（PD）和相关的帕金森综合征、阿尔茨海默病、创伤性脑损伤，甚至在正常衰老中。虽然不知道会产生自身免疫反应，但我们假设疾病中聚集的tau和p-tau的出现可以激活免疫系统。因此，我们比较了PD患者、年龄匹配的健康对照和年轻健康对照之间对tau和p-tau衍生肽的T细胞应答。
Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders, including Parkinson disease (PD) and related parkinsonisms, Alzheimer disease, traumatic brain injury, and even in normal aging. Although not known to produce autoimmune responses, we hypothesized that the appearance of aggregated tau and p-tau with disease could activate the immune system. We thus compared T cell responses to tau and p-tau-derived peptides between PD patients, age-matched healthy controls, and young healthy controls (