Hypoplasia and Hypodontia in Van der Woude Syndrome
Hypoplasia and Hypodontia in Van der Woude Syndrome
复制标题
范德沃德综合征中的发育不全和牙齿发育不全
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
K. Vargervik
中科院分区：
文献类型：
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作者：
S. Oberoi;K. Vargervik
目的研究货车德沃德综合征（VWS）患者上颌骨发育情况，并与正常对照组进行比较。设计和设置回顾性病例对照研究，来自加州大学弗朗西斯科分校颅面畸形中心，加州。患者和参与者样本包括15名货车der Woude综合征患者和15名非综合征性唇腭裂对照组，年龄范围为5至13岁，年龄、性别和唇腭裂类型配对。主要结果：数字化头颅骨密度片，并进行31个线性和角度测量。使用连续全景X光照片来评估恒牙的存在或缺失。结果货车der Woude综合征患者的上颌骨矢状位（以面中长（Co-A）表示）明显短于对照组（p = 0.031），提示上颌骨发育不良的趋势更明显，尤其是在伴有双侧唇腭裂的货车der Woude综合征患者中。货车der Woude综合征患儿的矢状颌关系（ANB角和Wits）测量值显著小于对照组（p = 0.008和p = 0.006）。货车德沃德综合征患者的缺牙数量显著高于对照组（p = 0.014）。货车德沃德综合征患儿下颌第二前磨牙缺失的频率高于对照组（p = 0.031）。上颌骨发育不全和缺牙的差异在更严重的裂型中最为显著，以双侧唇裂和/或腭裂为代表。结论根据这些发现，预计范德沃德综合征的上颌骨发育不全和缺牙的严重程度将高于非综合征性唇裂。货车德沃德综合征。
Objective The purpose of this study was (1) to assess maxillary development in cleft individuals with Van der Woude syndrome (VWS) and (2) to compare hypodontia in VWS and nonsyndromic cleft matched controls. Design and Setting Retrospective case-control study from the Center for Craniofacial Anomalies, University of California, San Francisco, California. Patients and Participants The sample consisted of 15 individuals with Van der Woude syndrome and 15 nonsyndromic cleft lip and/or palate controls paired for age, gender, and cleft type in the age range of 5 to 13 years. Main Outcome Measures Cephalograms were digitized, and 31 linear and angular measurements were made. Serial panoramic radiographs were used to assess the presence or absence of permanent teeth. Results The maxillary sagittal position represented by midface length (Co-A) was significantly shorter in the Van der Woude syndrome subjects than in the matched controls (p = .031), suggesting a trend towards greater maxillary hypoplasia, particularly in Van der Woude syndrome with bilateral cleft lip and/ or palate. Measurements indicating sagittal jaw relationship (ANB angle and the Wits) were significantly smaller in the children with Van der Woude syndrome than in matched controls (p = .008 and p = .006). A significantly larger number of individuals with Van der Woude syndrome than matched controls had missing teeth (p = .014). The mandibular second premolar was missing more frequently in children with Van der Woude syndrome than in the matched controls (p = .031). The differences concerning both maxillary hypoplasia and hypodontia were most marked in the more severe cleft type, represented by bilateral cleft lip and/or palate. Conclusions Based on these findings, the expectation is that there will be maxillary hypoplasia and hypodontia of greater severity in Van der Woude syndrome than in nonsyndromic clefts.
影响因子：
9.8
作者：
J. C. Murray;D. Nishimura;K. Buetow;H. Ardinger;M. Spence;R. Sparkes;R. Falk;P. Falk;R. Gardner;E. Harkness;L. Glinski;R. Pauli;Yusuke Nakamura;P. Green;A. Schinzel
通讯作者：
J. C. Murray;D. Nishimura;K. Buetow;H. Ardinger;M. Spence;R. Sparkes;R. Falk;P. Falk;R. Gardner;E. Harkness;L. Glinski;R. Pauli;Yusuke Nakamura;P. Green;A. Schinzel
完善 Van der Woude 基因定位并构建跨越 1q32-q41 关键区域的 3.5-Mb YAC 重叠群和 STS 图谱。
DOI：
10.1006/geno.1996.0496
发表时间：
1996
期刊：
Genomics.
影响因子：
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作者：
Schutte,BC;Sander,A;Malik,M;Murray,JC
通讯作者：
Murray,JC