Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study
Significance of intraplaque neovascularisation for vulnerability: optical coherence tomography study
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DOI：
10.1136/heartjnl-2012-302445
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发表时间：
2012-10-01
期刊：
影响因子：
5.7
通讯作者：
Jang, Ik-Kyung
中科院分区：
文献类型：
--
作者：
Tian, Jinwei;Hou, Jingbo;Jang, Ik-Kyung
本研究旨在利用光学相干断层扫描（OCT）研究斑块内新生血管（NV）在不稳定型心绞痛（UAP）的罪魁祸首病变和非罪魁祸首病变以及稳定型心绞痛（SAP）病变中的作用。设计本研究为回顾性研究。NV对罪魁和非罪魁斑块的意义尚不清楚。92例UAP患者和25例SAP患者共356个斑块接受OCT成像，分为三组：UAP的罪魁祸首病变（92），UAP的非罪魁祸首病变（203）和SAP病变（61）。通过OCT检查NV和斑块特征，并比较有无NV的斑块。结果在UAP罪魁祸首病变中，NV斑块的薄帽纤维粥样瘤发生率明显高于无NV斑块（81% vs 47%, p=0.002）。此外，纤维帽更薄（56 +/- 20 μ m vs 75 +/- 30 μ m, p=0.002）
Objectives This study aimed to investigate the role of intraplaque neovascularisation (NV) in culprit lesions and non-culprit lesions of unstable angina pectoris (UAP) and in lesions of stable angina pectoris (SAP) using optical coherence tomography (OCT).Design This study was a retrospective study.Setting The significance of NV for culprit and non-culprit plaques remains unclear.Participants A total of 356 plaques from 92 UAP patients and 25 SAP patients who underwent OCT imaging were divided into three groups: culprit lesions in UAP (92), non-culprit lesions in UAP (203) and lesions of SAP (61).Main outcome measures NV and plaque characteristics were examined by OCT and plaques with and without NV were compared.Results Among UAP culprit lesions, plaques with NV had significantly higher incidence of thin cap fibroatheroma (81% vs 47%, p=0.002) compared with those without NV. In addition, the fibrous cap was thinner (56 +/- 20 mu m vs 75 +/- 30 mu m, p