Lymphoid and non-lymphoid cells in nasal-associated lymphoid tissue (NALT) in the rat
Lymphoid and non-lymphoid cells in nasal-associated lymphoid tissue (NALT) in the rat
复制标题
大鼠鼻相关淋巴组织 (NALT) 中的淋巴细胞和非淋巴细胞
DOI：
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发表时间：
1990
影响因子：
3.6
通讯作者：
Taede Sminia
中科院分区：
文献类型：
--
作者：
C. Kuper;D. M. Hameleers;J. Bruijntjes;I. Ven;J. Biewenga;Taede Sminia
应用免疫组织化学和酶组织化学方法对大鼠鼻腔粘膜相关淋巴组织的淋巴细胞和巨噬细胞亚群及间质进行了观察。鼻相关淋巴组织由淋巴细胞和巨噬细胞组成的松散的网状网络组成，被上皮覆盖。上皮细胞浸润有B细胞、T辅助细胞（W3/13阳性）和T抑制细胞/细胞毒性或大颗粒细胞（OX 8阳性）、ED 1阳性巨噬细胞和Ia阳性细胞。B细胞区域由表面IgM或IgG免疫阳性的B细胞占据。表面有伊加或IgE的B细胞很少。老年中心很少被发现。辅助性T细胞散在分布于B细胞区。少数ED 1阳性巨噬细胞和ED 5阳性滤泡树突状细胞。在该区域发现强Ia染色（主要是B细胞）。T细胞区域含有大约等量的T辅助细胞和T抑制细胞/细胞毒性细胞，以及大量ED 1阳性巨噬细胞。ED 1染色也见于上皮下区域。在淋巴团与周围结缔组织的交界处发现大量ED 1、ED 2和ED 3阳性巨噬细胞。少数非淋巴细胞显示弱酸性磷酸酶或非特异性酯酶活性。形态学观察表明，鼻相关淋巴组织在吸入抗原的首次接触中起重要作用。
SummaryLymphocyte and macrophage subpopulations and the stroma of mucosa-associated lymphoid tissue in the nasal cavity of the rat were examined by application of immunohistochemical and enzyme histochemical methods to cryostat sections. Nasal-associated lymphoid tissue was composed of a loose reticular network with lymphocytes and macrophages, covered by epithelium. The epithelium was infiltrated with B cells, T helper (W3/13-positive) and T suppressor/cytotoxic or large granular cells (OX8-positive), ED1-positive macrophages and Ia-positive cells. The B cell areas were populated by B cells, immunopositive for surface IgM or IgG. B cells with surface IgA or IgE were rare. Germinal centres were found infrequently. T helper cells were scattered throughout the B cell area. A few ED1-positive macrophages and ED5-positive follicular dendritic cells were observed. Strong Ia staining (mostly of B cells) was found in this area. The T cell areas contained T helper and T suppressor/cytotoxic cells in about equal amounts, and numerous ED1-positive macrophages. ED1 staining was also found in the subepithelial area. Numerous ED1-, ED2- and ED3-positive macrophages were found in the border between the lymphoid mass and the surrounding connective tissue. A few non-lymphoid cells showed weak acid phosphatase or non-specific esterase activity. The morphological observations suggest that nasal-associated lymphoid tissue plays an important role in the first contact with inhaled antigens.
帽猴鼻腔的非嗅觉表面上皮：移行上皮和呼吸道上皮的形态学和形态测量研究。
DOI：
10.1002/aja.1001800308
发表时间：
1987
期刊：
The American journal of anatomy
影响因子：
--
作者：
Harkema,JR;Plopper,CG;Hyde,DM;Wilson,DW;StGeorge,JA;Wong,VJ
通讯作者：
Wong,VJ