Control of Drosophila eye specification by Wingless signalling
Control of Drosophila eye specification by Wingless signalling
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DOI：
10.1242/dev.00096
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发表时间：
2002-12-01
期刊：
影响因子：
4.6
通讯作者：
Freeman, M
中科院分区：
文献类型：
--
作者：
Baonza, A;Freeman, M
器官的形成需要及早确定形成特定结构的细胞组。这种没有翅膀的蛋白质在果蝇这种意象结构的区域性规范中扮演着重要的角色，包括定义眼睛触角圆盘将成为视网膜的区域。我们发现，无翼信号通过抑制眼睛指定基因Eyes、Sine Oculis和Dachshund的表达，在视网膜和相邻的头部结构之间建立了边界。异位的无翼信号会导致这些基因的抑制和眼睛的丧失，而失去无翼信号则有相反的效果。野生型视盘前部的无翼表达与这些眼睛特定基因的表达是互补的。与以前的报道相反，我们发现在过度无翼信号的条件下，眼睛组织不仅转化为头部角质层，还转化为各种不适当的结构。
Organ formation requires early specification of the groups of cells that will give rise to specific structures. The Wingless protein plays an important part in this regional specification of imaginal structures in Drosophila, including defining the region of the eye-antennal disc that will become retina. We show that Wingless signalling establishes the border between the retina and adjacent head structures by inhibiting the expression of the eye specification genes eyes absent, sine oculis and dachshund. Ectopic Wingless signalling leads to the repression of these genes and the loss of eyes, whereas loss of Wingless signalling has the opposite effects. Wingless expression in the anterior of wild-type discs is complementary to that of these eye specification genes. Contrary to previous reports, we find that under conditions of excess Wingless signalling, eye tissue is transformed not only into head cuticle but also into a variety of inappropriate structures.