Dioctadecyl L-glutamide-derived lipid-grafted silica as a novel organic stationary phase for RP-HPLC.
Dioctadecyl L-glutamide-derived lipid-grafted silica as a novel organic stationary phase for RP-HPLC.
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DOI：
10.1016/j.chroma.2005.03.090
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发表时间：
2005-05
期刊：
影响因子：
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通讯作者：
M. Takafuji;M. Rahman;H. R. Ansarian;Mahnaz Derakhshan;T. Sakurai;H. Ihara
中科院分区：
文献类型：
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作者：
M. Takafuji;M. Rahman;H. R. Ansarian;Mahnaz Derakhshan;T. Sakurai;H. Ihara
已经发现二烷基L-藜芦酰胺衍生的脂质形成超分子组装体，并且基于它们在水和有机介质中的高度有序结构显示出特定的性质。为了利用这些独特的性质来创建分子识别系统，新制备了双十八烷基L-藜芦酰胺衍生的脂质接枝的多孔二氧化硅颗粒（Sil-DSG），并将其用作反相液相色谱中的固定相。与常规ODS（十八烷基硅胶）柱相比，Sil-DSG柱对多环芳烃（PAHs）具有更高的选择性。特别是Sil-DSG识别了多环芳烃分子的线性和平面性。悬浮态的~ 1H NMR和~（13）C CP/MAS-NMR谱表明，Sil-DSG上的烷基链呈弯曲状，在室温下其移动性受到很强的限制。本文讨论了具有羰基π-苯π相互作用的Sil-DSG的高选择性。
Dialkyl l-glutamide-derived lipids have been found to form supramolecular assemblies and to show specific properties based on their highly ordered structures in aqueous and organic media. To use these unique properties to create molecular recognition systems, dioctadecyl l-glutamide-derived lipid-grafted porous silica particles (Sil-DSG) were newly prepared and used as a stationary phase in reversed phase liquid chromatography. Compared with conventional ODS (octadecylated silica), the Sil-DSG column showed remarkably higher selectivity for polycyclic aromatic hydrocarbons (PAHs). Especially, Sil-DSG recognized the molecular linearity and planarity of PAHs. Suspension state1H NMR and13C CP/MAS-NMR spectroscopies showed that the alkyl chains on the Sil-DSG are in gauche form and their mobility is strongly restricted at room temperature. This paper discusses higher selectivity of Sil-DSG with a carbonyl π-benzene π interactions.