Comparison of Four Lasers (λ = 650, 808, 980, and 1075 nm) for Noninvasive Creation of Deep Subsurface Lesions in Tissue.
Comparison of Four Lasers (λ = 650, 808, 980, and 1075 nm) for Noninvasive Creation of Deep Subsurface Lesions in Tissue.
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四种激光（λ = 650、808、980 和 1075 nm）在组织中无创产生深层地下病变的比较。
DOI：
10.1117/12.2183478
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Fried,NathanielM
中科院分区：
文献类型：
--
作者：
Chang,Chun-Hung;Wilson,ChristopherR;Fried,NathanielM
激光与冷却方法相结合，可在整容手术期间保留浅表皮肤层（100 微米）。保留较厚的组织表层（毫米）也可能允许开发其他非侵入性激光手术。我们正在探索泌尿外科中的无创激光治疗应用（例如激光输精管切除术和激光治疗女性压力性尿失禁），这需要毫米级的表面组织保存。在这项初步研究中，比较了四种激光对深层地下热损伤的无创产生。来自三个二极管激光器（650、808 和 980 nm）和镱光纤激光器（1075 nm）的激光能量通过带有集成冷却功能的定制侧面发射激光探头提供。温度为 5°C 的酒精溶液通过流通池循环，冷却蓝宝石窗口，进而冷却组织表面。将探针放置在离体猪肝组织接触处，在盐水中保持水合并维持在～35℃。入射激光功率为4.2W，光斑直径为5.3mm，处理时间为60s。经测试，在组织接触冷却过程中产生深层地下热损伤的最佳激光波长为 1075 nm，可保留约 2 mm 的表层。镱光纤激光器提供了一种紧凑、低维护、高功率的替代激光源，可替代钕：YAG 激光器，用于无创热疗。
Lasers have been used in combination with applied cooling methods to preserve superficial skin layers (100’s µm’s) during cosmetic surgery. Preservation of a thicker tissue surface layer (millimeters) may also allow development of other noninvasive laser procedures. We are exploring noninvasive therapeutic laser applications in urology (eg laser vasectomy and laser treatment of female stress urinary incontinence), which require surface tissue preservation on the millimeter scale. In this preliminary study, four lasers were compared for noninvasive creation of deep subsurface thermal lesions. Laser energy from three diode lasers (650, 808, and 980 nm) and a Ytterbium fiber laser (1075 nm) was delivered through a custom built, side-firing, laser probe with integrated cooling. An alcohol-based solution at− 5 C was circulated through a flow cell, cooling a sapphire window, which in turn cooled the tissue surface. The probe was placed in contact with porcine liver tissue, ex vivo, kept hydrated in saline and maintained at~ 35 C. Incident laser power was 4.2 W, spot diameter was 5.3 mm, and treatment time was 60 s. The optimal laser wavelength tested for creation of deep subsurface thermal lesions during contact cooling of tissues was 1075 nm, which preserved a surface layer of~ 2 mm. The Ytterbium fiber laser provides a compact, low maintenance, and high power alternative laser source to the Neodymium: YAG laser for noninvasive thermal therapy.
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发表时间：
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期刊：
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作者：
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