Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
Teratogenic and Carcinogenic Effects in the Offspring after Single Injection of Ethylnitrosourea to Pregnant Rats
复制标题
妊娠大鼠单次注射乙基亚硝基脲对子代的致畸和致癌作用
作者：
H. Druckrey;S. Ivankovic;R. Preussmann
ALKYLNITROSOUREAS give the corresponding alkylating diazoalkanes on heterolysis, and are potent carcinogens, selectively producing malignant tumours in the brain1 and peripheral nerves2 of rats. As might be expected, mothylnitrosourea is also mutagenic as in Saccharomyces cerevisiae3 and is teratogenic in rats4. In teratogenesis investigations the embryos are generally killed and examined immediately after Caesarean delivery. If, however, only slight teratogenic effects are produced to allow the offspring to survive, cancer may also develop later on.
