Lung cancer survival in never-smokers and exposure to residential radon: Results of the LCRINS study
Lung cancer survival in never-smokers and exposure to residential radon: Results of the LCRINS study
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DOI：
10.1016/j.canlet.2020.05.022
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发表时间：
2020-09-01
期刊：
影响因子：
9.7
通讯作者：
Perez-Rios, Monica
中科院分区：
文献类型：
--
作者：
Casal-Mourino, Ana;Ruano-Ravina, Alberto;Perez-Rios, Monica
我们的目的是评估从不吸烟者的肺癌生存率，包括总体和具体的性别，住宅氡暴露，年龄，组织学类型和诊断阶段。我们包括在多中心，医院为基础的从不吸烟患者的病例对照研究中诊断的肺癌病例，包括369名从不吸烟者（79%为女性;中位年龄71岁; 80%为腺癌; 66%为IV期）。中位总生存期，在1年，3年和5年的诊断分别为18.3个月，61%，32%和22%。较高的中位生存率：年龄较小，腺癌，可操作的突变，在诊断早期。多因素分析显示，室内氡浓度越高，肺癌死亡风险越高，不吸烟者的肺癌中位生存率似乎高于常吸烟者。具有可操作突变的患者具有显著更高的存活率。较高的室内氡暴露对生存有负面影响。
We aimed to evaluate lung cancer survival in never-smokers, both overall and specifically by sex, exposure to residential-radon, age, histological type, and diagnostic stage.We included lung cancer cases diagnosed in a multicentre, hospital-based, case-control-study of never-smoker patients, diagnosed from January-2011 to March-2015 (Lung Cancer Research In Never Smokers study).369 never-smokers (79% women; median age 71 years; 80% adenocarcinoma; 66% stage IV) were included. Median overall survival, and at one, 3 and 5 years of diagnosis was 18.3 months, 61%, 32% and 22%, respectively. Higher median survival rates were obtained for: younger age, adenocarcinoma, actionable mutations, and earlier-stage at diagnosis. Higher indoor radon showed a higher risk of death in multivariate analysis.Median lung cancer survival in never-smokers seems higher than that in ever-smokers. Patients with actionable mutations have a significantly higher survival. Higher indoor-radon exposure has a negative effect on survival.