Effects of Streptococcus pneumoniae strain background on complement resistance.
Effects of Streptococcus pneumoniae strain background on complement resistance.
复制标题
肺炎链球菌菌株背景对补体耐药性的影响。
DOI：
10.1371/journal.pone.0024581
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Brown JS
中科院分区：
文献类型：
--
作者：
Hyams C;Opel S;Hanage W;Yuste J;Bax K;Henriques-Normark B;Spratt BG;Brown JS
Immunity to infections caused by Streptococcus pneumoniae is dependent on complement. There are wide variations in sensitivity to complement between S. pneumoniae strains that could affect their ability to cause invasive infections. Although capsular serotype is one important factor causing differences in complement resistance between strains, there is also considerable other genetic variation between S. pneumoniae strains that may affect complement-mediated immunity. We have therefore investigated whether genetically distinct S. pneumoniae strains with the same capsular serotype vary in their sensitivity to complement mediated immunity. C3b/iC3b deposition and neutrophil association were measured using flow cytometry assays for S. pneumoniae strains with different genetic backgrounds for each of eight capsular serotypes. For some capsular serotypes there was marked variation in C3b/iC3b deposition between different strains that was independent of capsule thickness and correlated closely to susceptibility to neutrophil association. C3b/iC3b deposition results also correlated weakly with the degree of IgG binding to each strain. However, the binding of C1q (the first component of the classical pathway) correlated more closely with C3b/iC3b deposition, and large differences remained in complement sensitivity between strains with the same capsular serotype in sera in which IgG had been cleaved with IdeS. These data demonstrate that bacterial factors independent of the capsule and recognition by IgG have strong effects on the susceptibility of S. pneumoniae to complement, and could therefore potentially account for some of the differences in virulence between strains.
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影响因子：
64.5
作者：
Kang, YS;Do, YY;Park, CG
通讯作者：
Park, CG
影响因子：
1.6
作者：
Jönsson, G;Truedsson, L;Sjöholm, AG
通讯作者：
Sjöholm, AG
影响因子：
3.1
作者：
Melin, Merit;Di Paolo, Emmanuel;Vakevainen, Merja
通讯作者：
Vakevainen, Merja
影响因子：
3.1
作者：
Melin, Merit;Jarva, Hanna;Vakevainen, Merja
通讯作者：
Vakevainen, Merja
影响因子：
3.1
作者：
Hyams, Catherine;Yuste, Jose;Brown, Jeremy S.
通讯作者：
Brown, Jeremy S.