BRUCHS MEMBRANE IN PSEUDOXANTHOMA ELASTICUM - HISTOCHEMICAL, ULTRASTRUCTURAL, AND X-RAY MICROANALYTICAL STUDY OF MEMBRANE AND ANGIOID STREAK AREAS
BRUCHS MEMBRANE IN PSEUDOXANTHOMA ELASTICUM - HISTOCHEMICAL, ULTRASTRUCTURAL, AND X-RAY MICROANALYTICAL STUDY OF MEMBRANE AND ANGIOID STREAK AREAS
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DOI：
10.1007/bf00409836
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发表时间：
1977-01-01
期刊：
影响因子：
--
通讯作者：
JENSEN, OA
中科院分区：
文献类型：
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作者：
JENSEN, OA
本文对1例弹性假性黄瘤（PXE）进行了组织化学、超微结构和元素分析。观察到两种类型的钙化，一种由羟基磷灰石组成，另一种由CaHPO4组成。它们分别出现在血管样条纹区瘢痕组织和血管样条纹区外的膜上。此外，在膜中发现了一种丝状物质以及酸性粘多糖的增加。本文讨论了血管样条纹钙化的发生和发病机制。作者赞成以畸形胶原蛋白作为PXE的基本缺陷。
In a case of pseudoxanthoma elasticum (PXE), Bruch's membrane was studied histochemically, ultrastructurally and by element analysis. Two kinds of calcifications were observed, one composed of hydroxyapatite and the other of CaHPO4. They were seen in the scar tissue of angioid streak areas and in the membrane outside these areas, respectively. Furthermore, a thready material was found in the membrane as well as an increased amount of acid mucopolysaccharides. The genesis of the calcifications and the pathogenesis of angioid streaks are discussed. The author is in favor of a malformed collagen as the basic defect in PXE.