Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism.
Anti-CD2 Antibody-Coated Nanoparticles Containing IL-2 Induce NK Cells That Protect Lupus Mice via a TGF-β-Dependent Mechanism.
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DOI：
10.3389/fimmu.2020.583338
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发表时间：
2020
影响因子：
7.3
通讯作者：
La Cava A
中科院分区：
文献类型：
--
作者：
Horwitz DA;Liu A;Bickerton S;Castaldo G;Matarese G;Fahmy TM;La Cava A
我们最近报道，用载有耐受性细胞因子的纳米颗粒 (NP) 进行治疗，可抑制将供体 CD4+ T 细胞从 DBA/2 小鼠转移到 (C57BL/6 × DBA/2)F1 (BDF1) 小鼠中诱导的狼疮样疾病的表现。尽管保护作用归因于适应性 CD4+ 和 CD8+ T 调节细胞的诱导，但结果表明可能涉及另一群免疫细胞。在这里，我们报告说，NK 细胞对于 NPs 赋予 BDF1 小鼠的狼疮样疾病的保护发挥着至关重要的作用，并且这种作用是 TGF-β 依赖性的。
We recently reported that the treatment with nanoparticles (NPs) loaded with tolerogenic cytokines suppressed the manifestations of lupus-like disease induced by the transfer of donor CD4+ T cells from DBA/2 mice into (C57BL/6 × DBA/2)F1 (BDF1) mice. Although the protective effects were ascribed to the induction of adaptive CD4+ and CD8+ T regulatory cells, the results suggested that another population of immune cells could be involved. Here we report that NK cells critically contribute to the protection from lupus-like disease conferred by NPs to BDF1 mice, and that this effect is TGF-β-dependent.