Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage
Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage
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DOI：
10.1016/j.leukres.2005.07.009
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发表时间：
2006-04-01
影响因子：
2.7
通讯作者：
Pistoia, V
中科院分区：
文献类型：
--
作者：
Corcione, A;Arduino, N;Pistoia, V
关于趋化因子受体在儿童b系急性淋巴细胞白血病（ALL）中的表达和功能的信息很少。我们检测了13例b前、17例早期b前、12例b前和9例B-ALL/伯基特淋巴瘤（BL）患儿CXCR1至CXCR5和CCR1至CCR7的表达。CXCR2、CXCR3和CXCR4在大多数病例中表达，而其他受体表达变化或缺失。CXCR4介导的所有白血病细胞亚型的趋化性。新分离的CCR7（+）早期前b - all细胞迁移到CCL19，而CCR7（+）前b -和前b - all细胞只有在可溶性重组CD40配体培养后才被CCL19吸引。(C) 2005 Elsevier Ltd版权所有。
Scanty information is available on chemokine receptor expression and function in childhood B-lineage acute lymphoblastic leukemia (ALL). Thirteen pro-B, 17 early pre-B, 12 pre-B, and 9 B-ALL/Burkitt lymphoma (BL) pediatric cases were tested for CXCR1 to CXCR5 and CCR1 to CCR7 expression. CXCR2, CXCR3, and CXCR4 were expressed in the majority of cases, while the other receptors were variably expressed or absent. CXCR4 mediated chemotaxis of all leukemic cell subtypes. Freshly isolated CCR7(+) early pre-B-ALL cells migrated to CCL19, whereas CCR7(+) pro-B- and pre-B-ALL cells were attracted by CCL19 only following culture with soluble recombinant CD40 ligand. (C) 2005 Elsevier Ltd. All rights reserved.