Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1.2017 to 17.1.2018: a cross-sectional study
Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1.2017 to 17.1.2018: a cross-sectional study
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DOI：
10.1186/s12879-019-3987-2
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发表时间：
2019-04-27
影响因子：
3.7
通讯作者：
Ahmadzadeh, Jamal
中科院分区：
文献类型：
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作者：
Mobaraki, Kazhal;Ahmadzadeh, Jamal
中东呼吸综合征冠状病毒（MERS-CoV）被认为是造成一种新的病毒流行和对全球卫生安全的紧急威胁的原因。本研究描述了中东呼吸综合征冠状病毒在世界范围内的流行病学现状。方法对世界卫生组织网站2017年1月1日至2018年1月17日疾病暴发新闻中记录的所有MERS-CoV病例数据进行流行病学分析。根据实验室确诊的中东呼吸综合征冠状病毒病例提取人口统计学和临床信息以及潜在接触者和可能的死亡危险因素。结果研究期间，世界卫生组织网站疫情新闻共记录MERS-CoV病例229例，死亡70例（30.5%）。根据本研究的现有细节，男女病死率均为30.5%(70/229)[男性32.1%(55/171)，女性25.8%(15/58)]。男性发病率[171例（74.7%）]高于女性[58例（25.3%）]。合并症和接触MERS-CoV病例等变量与MERS-CoV感染者的死亡率显著相关，调整后的优势比估计分别为2.2 （95% CI: 1.16, 7.03）和2.3 （95% CI: 1.35, 8.20）。所有年龄组的死亡率相同。结论在今天的地球村中，任何时间、任何地点都有可能发生MERS-CoV疫情，而无需事先通知。因此，所有国家的卫生系统都应对可能输入的中东呼吸综合征冠状病毒病例实施更好的分诊系统，以防止大规模流行。
BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) is considered to be responsible for a new viral epidemic and an emergent threat to global health security. This study describes the current epidemiological status of MERS-CoV in the world.MethodsEpidemiological analysis was performed on data derived from all MERS-CoV cases recorded in the disease outbreak news on WHO website between 1.1.2017 and 17.1.2018. Demographic and clinical information as well as potential contacts and probable risk factors for mortality were extracted based on laboratory-confirmed MERS-CoV cases.ResultsA total of 229 MERS-CoV cases, including 70 deaths (30.5%), were recorded in the disease outbreak news on world health organization website over the study period. Based on available details in this study, the case fatality rate in both genders was 30.5% (70/229) [32.1% (55/171) for males and 25.8% (15/58) for females]. The disease occurrence was higher among men [171 cases (74.7%)] than women [58 cases (25.3%)]. Variables such as comorbidities and exposure to MERS-CoV cases were significantly associated with mortality in people affected with MERS-CoV infections, and adjusted odds ratio estimates were 2.2 (95% CI: 1.16, 7.03) and 2.3 (95% CI: 1.35, 8.20), respectively. All age groups had an equal chance of mortality.ConclusionsIn today's global village, there is probability of MERS-CoV epidemic at any time and in any place without prior notice. Thus, health systems in all countries should implement better triage systems for potentially imported cases of MERS-CoV to prevent large epidemics.