The structure of the liquid-crystalline phasis of lipid-water systems.
The structure of the liquid-crystalline phasis of lipid-water systems.
复制标题
脂质 - 水系统的液晶质量的结构。
DOI：
10.1083/jcb.12.2.207
复制
发表时间：
1962-02
影响因子：
7.8
通讯作者：
HUSSON, F
中科院分区：
文献类型：
--
作者：
LUZZATI, V;HUSSON, F
用X射线散射技术研究了一些简单的脂类-水体系作为脂类浓度和温度的函数。已经发现了几个液晶相，并确定了它们的结构：其中只有一个是片状的。在所有这些相中，脂分子的碳氢化合物部分具有无序的类液体结构。用同样的技术研究了一种生物磷脂，一种人脑提取物，发现了两种液晶相：一种是由有序的脂类和水平面组成的片状相，另一种是由圆柱体组成的六角形阵列，每个圆柱体是一个被脂类分子的亲水基团覆盖的细水通道，碳氢链填补了圆柱体之间的间隙。讨论了对脂蛋白膜结构的电子显微镜观察的解释，并提出了一些可能的生物学意义。
Some simple lipid-water systems have been studied by x-ray scattering techniques, as a function of lipid concentration and temperature. Several liquid-crystalline phases have been found, and their structure has been determined: only one of these is lamellar. In all these phases the hydrocarbon part of the lipid molecules has a disordered, liquid-like structure. One biological phospholipid, a human brain extract, has been studied by the same technique, and two liquid-crystalline phases have been found: a lamellar phase, built up by an ordered sequence of lipid and water planar sheets, and a hexagonal phase, which is a hexagonal array of circular cylinders, each cylinder being a thin water channel covered by the hydrophilic groups of the lipid molecules, the hydrocarbon chains filling the gap between the cylinders. The interpretation of the electron microscope observations of the structure of lipoprotein membranes is discussed, and some possible biological implications are suggested.