FACTORS INFLUENCING REDOX POTENTIALS OF ELECTRON-TRANSFER PROTEINS
FACTORS INFLUENCING REDOX POTENTIALS OF ELECTRON-TRANSFER PROTEINS
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DOI：
10.1073/pnas.83.14.4998
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发表时间：
1986-07-01
影响因子：
11.1
通讯作者：
ROGERS, NK
中科院分区：
文献类型：
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作者：
MOORE, GR;PETTIGREW, GW;ROGERS, NK
电子传递蛋白的氧化还原电位在很宽的范围内变化，即使氧化还原中心的类型相同。Rees [Proc. Natl. Acad. Sci. USA（1985）82，3082-2085]提出氧化还原电位的这种变化部分地反映了蛋白质的不同净电荷，并且他提出了36种蛋白质的这两种性质之间的线性相关性。对影响蛋白质氧化还原电位的因素的回顾清楚地表明，这种线性相关性是偶然的。影响氧化还原电位的关键因素是两种氧化还原状态之间的吉布斯能差的贡献，这是由氧化还原中心的键合相互作用、氧化还原中心电荷与蛋白质和溶剂内的极性基团之间的静电相互作用以及氧化还原状态构象变化引起的。这些术语的相对重要性可能因蛋白质而异。
The redox potentials of electron transfer proteins vary over a wide range, even when the type of redox center is the same. Rees [Proc. Natl. Acad. Sci. USA (1985) 82, 3082-2085] proposed that this variation of redox potential partly reflects the different net charges of the proteins, and he presented a linear correlation between these two properties for 36 proteins. A review of the factors that influence protein redox potentials makes it clear that this linear correlation is fortuitous. The key factors influencing redox potentials are the contributions to the Gibbs energy difference between the two redox states, resulting from bonding interactions at the redox center, electrostatic interactions between the redox-center charge and polar groups within the protein and solvent, and redox-state conformational changes. The relative importance of these terms is likely to vary from protein to protein.