Patterning signals and proliferation in Drosophila imaginal discs
Patterning signals and proliferation in Drosophila imaginal discs
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DOI：
10.1016/j.gde.2007.05.005
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发表时间：
2007-08-01
影响因子：
4
通讯作者：
Baker, Nicholas E.
中科院分区：
文献类型：
--
作者：
Baker, Nicholas E.
最近的研究表明，在模式形成中具有众所周知作用的信号通路也直接调节细胞增殖。在视网膜分化过程中，Hedgehog、Decappentaplegic、Notch 和 EGF 受体通过对 string、dacapo 以及尚未识别的视网膜母细胞瘤和 Cyclin E/Cdk2 活性的尚未识别的调节因子的转录调节来调节空间增殖。在发育中的翅膀中，对十五麻痹信号传导不连续性的新反应与浓度依赖性效应相结合，以响应十五麻痹梯度而实现均匀的增殖模式。对生长组织的损伤可以通过死亡细胞短暂的十肢瘫痪和无翼分泌物来修复，从而诱导代偿性增殖。命运规范和增殖的不同空间模式可以通过信号通路的不同组合产生。让人想起模式的形成，每个信号通路的细胞周期效应在不同的发育领域中有所不同，利用了多种靶基因。
Recent studies indicate that signaling pathways with wellknown roles in patterning also directly regulate cell proliferation. During the differentiation of the retina, Hedgehog, Decapentaplegic, Notch and the EGF receptor regulate proliferation spatially through transcriptional regulation of string, dacapo, and as yet unidentified regulators of Retinoblastoma and Cyclin E/Cdk2 activities. In the developing wing, a novel response to discontinuities in Decapentaplegic signaling combines with concentration-dependent effects to achieve a uniform proliferation pattern in response to a Decapentaplegic gradient. Damage to growing tissues is repaired by transient Decapentaplegic and Wingless secretion from dying cells to induce compensatory proliferation. Diverse spatial patterns of fate specification and of proliferation can arise through distinct combinations of signaling pathways. Reminiscent of pattern formation, cell cycle effects of each signaling pathway differ in distinct developmental fields, making use of a variety of target genes.