Combination of sequence‐defined oligoaminoamides with transferrin‐polycation conjugates for receptor‐targeted gene delivery
Combination of sequence‐defined oligoaminoamides with transferrin‐polycation conjugates for receptor‐targeted gene delivery
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DOI：
10.1002/jgm.2838
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发表时间：
2015-08
期刊：
影响因子：
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通讯作者：
Wei Zhang;W. Rödl;Dongsheng He;M. Döblinger;Ulrich Lächelt;E. Wagner
中科院分区：
文献类型：
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作者：
Wei Zhang;W. Rödl;Dongsheng He;M. Döblinger;Ulrich Lächelt;E. Wagner
转铁蛋白受体（TfR）在大多数恶性细胞上过表达，作为药物、蛋白质和基因传递的靶点已被广泛研究。稳定的核酸紧密性和高效的细胞质溶胶基因释放能力是基因传递成功的关键。
Transferrin receptor (TfR), over‐expressed on a majority of malignant cells, has been widely studied as a target for drug, protein and gene delivery. Both stable nucleic acid compact ability and efficient cytosol gene release capability are essential for the success of gene delivery.