A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis
A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis
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DOI：
10.1021/acssensors.7b00961
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发表时间：
2018-05-01
期刊：
影响因子：
8.9
通讯作者：
Javey, Ali
中科院分区：
文献类型：
--
作者：
Nyein, Hnin Yin Yin;Tai, Li-Chia;Javey, Ali
可穿戴汗液传感是一个迅速崛起的研究领域，它在健康、健身和诊断应用方面具有巨大的潜力。尽管该领域有所增长，但与汗液指标相关的主要挑战仍有待解决。这些挑战包括汗率监测，因为它与汗液成分有复杂的关系，以及汗液采样用于汗液动力学研究。在这项工作中，我们提出了一种灵活的微流控汗液传感贴片，它通过汗液采样来增强实时电化学传感和汗率分析。该设备包含一个螺旋图案的微流体组件，该组件嵌入了离子选择传感器和基于电阻抗的出汗率传感器，该传感器位于柔性塑料基板上。通过将传感组件与能够现场信号调节、分析和传输的印刷电路板对接，贴片能够自主执行汗液分析。微流控装置中的渐进汗流由分泌的汗液诱导的压力控制，通过限定的汗液收集腔和定向汗液路线增强汗液采样和电化学检测。通过理论仿真验证了出汗率传感器的特性，并用商用注射泵和Macroduct型集汗器验证了流量测量的精确度和准确性。体内同时监测离子(H+、Na+、K+、Cl-)浓度和出汗率也是为了实现传感器功能。这款汗液传感贴片为全面的汗液分泌分析提供了一个集成平台，并通过密切监控相互关联的汗液参数，方便了生理和临床研究。
Wearable sweat sensing is a rapidly rising research area driven by its promising potential in health, fitness, and diagnostic applications. Despite the growth in the field, major challenges in relation to sweat metrics remain to be addressed. These challenges include sweat rate monitoring for its complex relation with sweat compositions and sweat sampling for sweat dynamics studies. In this work, we present a flexible microfluidic sweat sensing patch that enhances real-time electrochemical sensing and sweat rate analysis via sweat sampling. The device contains a spiral-patterned microfluidic component that is embedded with ion-selective sensors and an electrical impedance-based sweat rate sensor on a flexible plastic substrate. The patch is enabled to autonomously perform sweat analysis by interfacing the sensing component with a printed circuit board that is capable of on-site signal conditioning, analysis, and transmission. Progressive sweat flow in the microfluidic device, governed by the pressure induced by the secreted sweat, enhances sweat sampling and electrochemical detection via a defined sweat collection chamber and a directed sweat route. The characteristic of the sweat rate sensor is validated through a theoretical simulation, and the precision and accuracy of the flow rate is verified with a commercial syringe pump and a Macroduct sweat collector. On-body simultaneous monitoring of ion (H+, Na+, K+, Cl-) concentration and sweat rate is also demonstrated for sensor functionality. This sweat sensing patch provides an integrated platform for a comprehensive sweat secretion analysis and facilitates physiological and clinical investigations by closely monitoring interrelated sweat parameters.