Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures
Task-related differential dynamics of EEG alpha- and beta-band synchronization in cortico-basal motor structures
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DOI：
10.1111/j.1460-9568.2007.05417.x
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发表时间：
2007-03-01
影响因子：
3.4
通讯作者：
Curio, Gabriel
中科院分区：
文献类型：
--
作者：
Klostermann, Fabian;Nikulin, Vadim V.;Curio, Gabriel
运动相关处理导致神经元同步在多个脑电图 (EEG) 频率范围内的调制，包括 α 频段 (8-12 Hz) 和 β 频段 (14-30 Hz)。运动系统内不同部位的调制模式是否不同尚不清楚，但可以表明信息如何通过皮质基底网络传递。因此，我们比较了运动任务期间头皮、基底神经节和丘脑结构记录中的事件相关同步/去同步（ERS/ERD）。 13 名患者接受丘脑腹侧中间核 (VIM) 或丘脑底核 (STN) 的深部脑刺激，同时记录深度和头皮脑电图。他们使用预先提示的“Go”信号执行了一项选择反应任务，该信号对于按下左侧或右侧按钮具有指导意义。在 beta 频段，预提示和 Go 信号之后是 ERD，在任务执行之前就开始并在任务执行时达到峰值，在所有皮质和皮质下记录中都是如此。相比之下，仅在头皮处观察到类似的α带ERD，而在运动抑制性STN中观察到镜像ERS。在接受强烈体感传入的 VIM 中，Go 信号上的主要 α-ERD 直到运动反应才开始。这些与任务相关的 Alpha 和 Beta 频带动态的分离标记了皮质基底网络的功能多样性，这些网络在运动处理中同时活跃。 β 活动的统一下调表明整个运动系统的反运动操作模式，而 α 同步的位点依赖性过程则反映了运动准备和执行过程中功能不同的运动结构中活动水平的协调。
Movement-related processing results in the modulation of neuronal synchronization over several electroencephalography (EEG) frequency ranges, including alpha- (8-12 Hz) and beta-band (14-30 Hz). Whether modulation patterns differ across sites within the motor system remains unclear, but could denote how information is conveyed across the cortico-basal network. We therefore compared the event-related synchronization/desynchronization (ERS/ERD) in recordings from the scalp, basal ganglia and thalamic structures during a motor task. Simultaneous depth and scalp EEG were recorded in 13 patients, undergoing deep brain stimulation of the thalamic ventral intermediate nucleus (VIM) or the subthalamic nucleus (STN). They performed a choice-reaction task with pre-cued Go-signals, instructive for either left- or right-sided button presses. In the beta-band, pre-cues and Go-signals were followed by ERD starting well before and peaking at task execution, uniformly in all cortical and subcortical recordings. In contrast, a comparable alpha-band ERD was only seen at the scalp, whereas mirror-like ERS were observed in the motor-inhibitory STN. In VIM, which receives strong somatosensory afferences, a major alpha-ERD upon the Go-signal did not start until the motor response.These dissociations of task-related Alpha- and Beta-band dynamics tag a functional diversity in cortico-basal networks, which are simultaneously active in motor processing. Whereas the uniform downregulation of Beta-activity points to an anti-kinetic operation mode throughout the motor system, site-dependent courses of Alpha-synchronization rather reflect the coordination of activity levels in functionally divergent motor structures during the preparation and execution of movements.