Distribution differences of macular cones measured by AOSLO: Variation in slope from fovea to periphery more pronounced than differences in total cones.
Distribution differences of macular cones measured by AOSLO: Variation in slope from fovea to periphery more pronounced than differences in total cones.
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DOI：
10.1016/j.visres.2016.06.015
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发表时间：
2017-03
期刊：
影响因子：
1.8
通讯作者：
Burns SA
中科院分区：
文献类型：
--
作者：
Elsner AE;Chui TY;Feng L;Song HX;Papay JA;Burns SA
即使在屈光不正的健康年轻人中，视锥密度也存在很大的个体差异。我们调查了球果密度是否遵循一个简单的模型，即一些个体有更多的球果，或者个体在球果的数量和分布上是否存在差异。我们使用定制的自适应光学扫描激光检眼镜对36名屈光不正的健康年轻人的眼锥进行了量化。在距中心凹270、630、1480和2070微米处，平均视锥密度分别为43216±6039、27466±3496、14996±1563和12207±1278个/mm~2。630微米视网膜偏心时的视锥密度与2070微米时的视锥密度没有相关性，排除了视锥密度与偏心之间存在恒定或成比例关系的模型。中心黄斑视锥密度高的受试者周围视锥密度较低。球果密度比(2070：630微米)与630微米的球果密度呈负相关，与圆锥体向中心迁移的比例变化一致。我们使用时间数据和我们公布的颞经、鼻经、上经和下经的视锥密度，对中心半径为7度的总视锥进行了建模。我们计算出平均有221,000个锥体。总视锥细胞的变异系数为0.0767，但中心凹附近的样品变异系数更高。球果总数和与球果分布有关的其他发育因子都存在个体差异。
Large individual differences in cone densities occur even in healthy, young adults with low refractive error. We investigated whether cone density follows a simple model that some individuals have more cones, or whether individuals differ in both number and distribution of cones. We quantified cones in the eyes of 36 healthy young adults with low refractive error using a custom adaptive optics scanning laser ophthalmoscope. The average cone density in the temporal meridian was, for the mean ± SD, 43216 ± 6039, 27466 ± 3496, 14996 ± 1563, and 12207 ± 1278 cones /mm2 for 270, 630, 1480, and 2070 microns from the foveal center. Cone densities at 630 microns retinal eccentricity were uncorrelated to those at 2070 microns, ruling out models with a constant or proportional relation of cone density to eccentricity. Subjects with high central macula cone densities had low peripheral cone densities. The cone density ratio (2070 : 630 microns) was negatively correlated with cone density at 630 microns, consistent with variations in the proportion of peripheral cones migrating towards the center. We modelled the total cones within a central radius of 7 deg, using the temporal data and our published cone densities for temporal, nasal, superior, and inferior meridians. We computed an average of 221,000 cones. The coefficient of variation was 0.0767 for total cones, but higher for samples near the fovea. Individual differences occur both in total cones and other developmental factors related to cone distribution.