Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis.
Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis.
复制标题
调节血小板激活和凝结及其在血管损伤和动脉血栓形成中的作用。
DOI：
10.1016/j.iccl.2016.08.001
复制
发表时间：
2017-01
影响因子：
--
通讯作者：
Stalker TJ
中科院分区：
文献类型：
--
作者：
Tomaiuolo M;Brass LF;Stalker TJ
止血需要凝血系统、血小板、其他血细胞和血管损伤部位处的血管壁组分的严格调节的相互作用。如果反应受损，这种反应的失调可能导致过度出血，如果反应过度强烈，则可能导致病理性血栓形成伴血管闭塞和组织缺血。几十年来的广泛研究已经阐明了负责血小板活化和聚集的主要分子信号传导途径，并且靶向这些途径中的几种的抗血栓形成剂在临床上广泛使用。本文将总结最近的研究，这些多个血小板信号通路整合在时间和空间的血管损伤部位在体内产生最佳的止血反应的机制。
Hemostasis requires the tightly regulated interaction of the coagulation system, platelets, other blood cells and components of the vessel wall at a site of vascular injury. The dysregulation of this response may result in excessive bleeding if the response is impaired, and pathologic thrombosis with vessel occlusion and tissue ischemia if the response is overly robust. Extensive studies over several decades have elucidated the major molecular signaling pathways responsible for platelet activation and aggregation, and anti-thrombotic agents targeting several of these pathways are in widespread clinical use. This review will summarize more recent research examining mechanisms by which these multiple platelet signaling pathways are integrated in time and space at a site of vascular injury in vivo to produce an optimal hemostatic response.