Resorufin based fluorescence 'turn-on' chemodosimeter probe for nitroxyl (HNO)
Resorufin based fluorescence 'turn-on' chemodosimeter probe for nitroxyl (HNO)
复制标题
基于试卤灵的硝酰基 (HNO) 荧光“开启”化学剂量计探针
DOI：
10.1039/c5ra17837a
复制
发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Bhuniya, Sankarprasad
中科院分区：
文献类型：
--
作者：
Bobba, Kondapa Naidu;Zhou, Ying;Bhuniya, Sankarprasad
研制了一种细胞响应的、高选择性的HNO荧光显色化学剂量计探针。这种新的探针在HNO存在下显示出类似于30倍的荧光增强，并且在低至0.02 μ M的浓度下对HNO敏感。此外，它能够检测细胞环境以及活样本（例如C.优雅的。
A cellular responsive, highly selective fluorogenic and chromogenic chemodosimeter probe for HNO is developed. This new probe showed similar to 30 fold fluorescence enhancement in the presence of HNO and is sensitive to HNO at concentrations as low as 0.02 mu M. Further, it is capable of detecting HNO levels in cellular milieus as well as in live specimens e.g. C. elegans.