Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2
Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2
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DOI：
10.1016/j.biolcel.2004.03.010
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发表时间：
2004-08-01
影响因子：
2.7
通讯作者：
Ostareck, DH
中科院分区：
文献类型：
--
作者：
Ostareck-Lederer, A;Ostareck, DH
对造血细胞基因表达转录后调节的研究发现，异质核核糖核蛋白（hnRNP）亚家族参与细胞质基因调节。HnRNP K和hnRNP E1/E2共享共同的结构基序，即hnRNP K同源（KH）结构域，其为mRNA结合提供了结构基础。KH结构域是模块化系统的组成部分，其使这些蛋白质能够参与蛋白质/核酸和蛋白质/蛋白质相互作用，后者产生与细胞信号传导事件的连接。hnRNP K和hnRNP E1/E2作为不同mRNA-蛋白复合物的组分，在造血细胞分化中控制mRNA翻译和mRNA稳定性。(C)2004年，Elsevier SAS。All rights reserved.
Studies on the post-transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH-domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA-protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation. (C) 2004 Elsevier SAS. All rights reserved.