Growth hormone regulation by growth hormone-releasing hormone in infant rhesus monkeys.
Growth hormone regulation by growth hormone-releasing hormone in infant rhesus monkeys.
复制标题
幼年恒河猴中生长激素释放激素对生长激素的调节。
DOI：
10.1159/000243384
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Styne,DM
中科院分区：
文献类型：
--
作者：
Wheeler,MD;Wehrenberg,WW;Styne,DM
为了研究内源性GHRH与新生灵长类动物血清GH浓度变化的关系，我们通过急性放置的静脉导管向1-31日龄的未麻醉禁食恒河猴施用GHRH抗血清（GHRH-Ab）或GHRH拮抗剂（N-Acetyl-Tyr 1，D-Arg 2）GHRH-（1-29）-NH 2。GHRH-Ab可显著降低1-2日龄和7-9日龄仔猪血清GH浓度，但对28-31日龄仔猪无显著影响。GHRH拮抗剂可使1-2日龄血清GH浓度显著降低，但对7日龄和14日龄无显著影响。这些结果表明，基础血清GH在1-2日龄比7-28日龄后更依赖于内源性GHRH。这表明生长激素分泌的下丘脑调节随着年龄的增长，在新生儿期的发展变化。
To study the relationship of endogenous GHRH to the changes seen in serum GH concentration in neonatal primates, we administered antiserum to GHRH (GHRH-Ab) or GHRH antagonist, (N-Acetyl-Tyr1,D-Arg2)GHRH-(1-29)-NH2, to unanesthetized, fasted rhesus monkeys, 1–31 days of age, via an acutely placed venous catheter. The administration of GHRH-Ab resulted in a significant decrease in serum GH concentration at 1–2 and 7–9 days, but not at 28–31 days of age. The administration of GHRH antagonist resulted in a significant decrease in serum GH concentrations at 1–2 days, but not at 7 or 14 days of age. These results imply that basal serum GH is more dependent on endogenous GHRH at 1–2 days than after 7–28 days of age. This suggests developmental changes in the hypothalamic regulation of GH secretion with advancing age in the neonatal period.