Understanding how we age: insights into inflammaging.
Understanding how we age: insights into inflammaging.
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DOI：
10.1186/2046-2395-2-8
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发表时间：
2013-05-02
期刊：
影响因子：
--
通讯作者：
Roberts HC
中科院分区：
文献类型：
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作者：
Baylis D;Bartlett DB;Patel HP;Roberts HC
炎症的特点是随着年龄的增长而出现炎症反应的上调；它的根源深深植根于进化论。炎症被认为是先天和获得性免疫系统重塑的结果，导致慢性炎症细胞因子的产生。复杂的相互关联的遗传、环境和年龄相关因素决定了一个人对炎症的脆弱性或复原力。这些因素包括细胞因子启动子区域、细胞因子受体和拮抗剂的多态性、与年龄相关的自噬减少和肥胖增加。抗炎是指下丘脑-垂体轴对炎症反应的上调，导致皮质醇水平升高，这反过来可能是有害的，导致不太成功的衰老和虚弱。这可能会被肾上腺类固醇脱氢表雄酮抵消，它本身会随着年龄的增长而下降，使某些人更容易受到伤害。消炎和抗炎都与许多与年龄相关的结果有关，包括慢性发病率、功能下降和死亡率。这一重要的研究领域为衰老过程以及筛查和有针对性干预的潜力提供了独特的见解。
Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory. Inflammaging is believed to be a consequence of a remodelling of the innate and acquired immune system, resulting in chronic inflammatory cytokine production. Complex interrelated genetic, environmental and age-related factors determine an individual’s vulnerability or resilience to inflammaging. These factors include polymorphisms to the promoter regions of cytokines, cytokine receptors and antagonists, age-related decreases in autophagy and increased adiposity. Anti-inflammaging describes the upregulation of the hypothalamic-pituitary axis in response to inflammaging, leading to higher levels of cortisol, which in turn may be detrimental, contributing to less successful ageing and frailty. This may be countered by the adrenal steroid dehydroepiandrosterone, which itself declines with age, leaving certain individuals more vulnerable. Inflammaging and anti-inflammaging have both been linked with a number of age-related outcomes, including chronic morbidity, functional decline and mortality. This important area of research offers unique insights into the ageing process and the potential for screening and targeted interventions.