CHOLINERGIC-INDUCED AND NEUROLEPTIC-INDUCED CATALEPSY - MODIFICATION BY LESIONS IN CAUDATE-PUTAMEN
CHOLINERGIC-INDUCED AND NEUROLEPTIC-INDUCED CATALEPSY - MODIFICATION BY LESIONS IN CAUDATE-PUTAMEN
复制标题
DOI：
10.1016/0028-3908(71)90053-0
复制
发表时间：
1971-01-01
影响因子：
4.7
通讯作者：
OLLEY, JE
中科院分区：
文献类型：
--
作者：
COSTALL, B;OLLEY, JE
氟哌啶醇和槟榔碱均可诱导大鼠出现强直状态，并且在这两种药物联合阈值剂量时观察到显着的协同效应。硫酸阿托品（而非硝酸甲酯阿托品）可阻断两种药物单独或联合使用的强直作用。双侧尾壳核损伤增强了槟榔碱的强直作用，同时显着降低了氟哌啶醇的强直作用。对双侧尾壳核病变的动物联合使用两种药物后，仅观察到槟榔碱的增强作用。尾壳核的单侧损伤对槟榔碱僵直症没有显着影响，但部分降低了氟哌啶醇及其组合的僵直作用。讨论了锥体外系在这些作用中的可能作用。
Both haloperidol and arecoline induced a cataleptic state in rats and a marked synergistic effect was observed upon combination of threshold doses of these two drugs. Atropine sulphate, but not atropine methylnitrate, blocked the cataleptic effects of the two drugs alone and in combination.Bilateral lesions of the caudate-putamen potentiated the cataleptic effect of arecoline whilst markedly reducing the cataleptic effect of haloperidol. Only the potentiated effect of arecoline was observed upon administration of a combination of the two drugs to animals with bilateral caudate-putamen lesions. Unilateral lesions of the caudate-putamen had no significant effect upon arecoline catalepsy but partially reduced the cataleptic effects of haloperidol and the combination.The possible role of the extrapyramidal system in these effects is discussed.