Multiple sclerosis - Neurofilament light chain antibodies are correlated to cerebral atrophy
Multiple sclerosis - Neurofilament light chain antibodies are correlated to cerebral atrophy
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DOI：
10.1212/01.wnl.0000041496.58127.e3
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发表时间：
2003-01-28
期刊：
影响因子：
9.9
通讯作者：
Uitdehaag, BMJ
中科院分区：
文献类型：
--
作者：
Eikelenboom, MJ;Petzold, A;Uitdehaag, BMJ
目的：评价不同亚型MS患者CSF和血清中轴突损伤标志物与MRI疾病进展指标的关系。研究方法：在51例MS患者（21例复发缓解型，20例继发性进展型，10例原发性进展型）中，分析了重和轻神经丝（NfH和NfL）和神经丝抗体（抗NfL和-NfH）以及总免疫球蛋白G（IgG）的水平。MRI分析包括T2高信号、T1低信号和钆增强病变以及脑萎缩的标志物（脑室和脑实质分数）。结果如下：对于总组，抗NfL指数与实质分数（PF）（r =-0.51，p < 0.001）、T2病变负荷（r = 0.41，p < 0.05）、心室分数（r = 0.37，p < 0.05）和T1病变负荷（r = 0.37，p < 0.05）之间存在相关性。抗NfH指数与PF呈正相关（r =-0.39，p < 0.05）。IgG指数和MRI测量之间没有发现相关性。结论：鞘内抗NfL抗体的产生可作为MS中组织损伤，特别是轴突缺失的标志物。
Objective: To evaluate markers of axonal damage in CSF and serum of patients with different subtypes of MS in relation to measures of disease progression on MRI. Methods: In 51 patients with MS (21 relapsing-remitting, 20 secondary progressive, 10 primary progressive), levels of heavy and light neurofilaments (NfH and NfL) and antibodies to neurofilaments (anti-NfL and -NfH) as well as the total immunoglobulin G (IgG) were analyzed. MRI analysis included T2 hyperintense, T1 hypointense, and gadolinium enhancing lesions and markers of cerebral atrophy (ventricular and parenchymal fractions). Results: For the total group, correlations were found between the anti-NfL index and the parenchymal fraction (PF) (r = -0.51, p < 0.001), T2 lesion load (r = 0.41, p < 0.05), ventricular fraction (r = 0.37, p < 0.05), and T1 lesion load (r = 0.37, p < 0.05). For the anti-NfH index, a correlation was found with the PF (r = -0.39, p < 0.05). No correlations were found between the IgG index and MRI measures. Conclusions: Intrathecal production of anti-NfL antibodies may serve as a marker of tissue damage, particularly axonal loss, in MS.