Translational MR Neuroimaging of Stroke and Recovery.
Translational MR Neuroimaging of Stroke and Recovery.
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中风和恢复的平移磁共振神经成像。
DOI：
10.1007/s12975-016-0497-z
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发表时间：
2017-02
影响因子：
6.9
通讯作者：
Mandeville JB
中科院分区：
文献类型：
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作者：
Mandeville ET;Ayata C;Zheng Y;Mandeville JB
多参数磁共振成像 (MRI) 已成为诊断局灶性缺血性中风严重程度、分期治疗和预测结果的重要临床工具。急性期的成像重点关注中风附近的组织活力，而恢复期的成像则需要评估分布式结构和功能连接。实验性中风模型的临床前 MRI 可以在细胞和分子机制方面验证非侵入性生物标志物，同时还为评估前瞻性疗法提供转化平台。这篇对转化性中风成像的简要回顾讨论了急性到慢性成像的转变、中风研究中常用 MRI 方法的原理，以及通过临床和临床前成像获得的实验结果，以确定组织活力、血管重塑、主要白质束的结构连接性以及中风恢复过程中使用基于任务和静息态 fMRI 的功能连接性。
Multiparametric magnetic resonance imaging (MRI) has become a critical clinical tool for diagnosing focal ischemic stroke severity, staging treatment, and predicting outcome. Imaging during the acute phase focuses on tissue viability in the stroke vicinity, while imaging during recovery requires the evaluation of distributed structural and functional connectivity. Preclinical MRI of experimental stroke models provides validation of non-invasive biomarkers in terms of cellular and molecular mechanisms, while also providing a translational platform for evaluation of prospective therapies. This brief review of translational stroke imaging discusses the acute to chronic imaging transition, the principles underlying common MRI methods employed in stroke research, and experimental results obtained by clinical and preclinical imaging to determine tissue viability, vascular remodeling, structural connectivity of major white matter tracts, and functional connectivity using task-based and resting-state fMRI during the stroke recovery process.