Changes in serum 3,3',5'-triiodothyronine (reverse T3) concentrations with altered thyroid hormone secretion and metabolism.
Changes in serum 3,3',5'-triiodothyronine (reverse T3) concentrations with altered thyroid hormone secretion and metabolism.
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血清 3,3,5-三碘甲状腺原氨酸（反向 T3）浓度的变化随甲状腺激素分泌和代谢的改变而变化。
DOI：
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发表时间：
1977
影响因子：
5.8
通讯作者：
R. D. Utiger
中科院分区：
文献类型：
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作者：
Michael M. Kaplan;M. Schimmel;R. D. Utiger
采用8-苯胺萘- 6-磺酸（ANS）抑制血清中3,3 ',5 ' -三碘甲状腺原氨酸（rT3）与血清蛋白的结合，建立了一种灵敏的放射免疫测定法。正常血清r≠23±8 (SD) ng/dl。甲状腺机能亢进患者（90±49 ng/dl）、甲状腺机能亢进患者（36±13 ng/dl）、孕妇（49±9 ng/dl）和脐带血患者（280±143 ng/dl）血清rT3浓度升高。甲状腺功能减退患者血清rT3浓度降低（14±5 ng/dl），与正常人相比，在给药期间rT3浓度下降。在接受T4替代治疗的甲状腺功能减退患者中，血清rT3浓度在0.050 ~ 0.3 mg/天的剂量范围内与T4剂量直接变化。甲状腺功能减退和甲亢患者血清rT3 / T4比值升高，而接受T4替代治疗的甲状腺功能减退患者血清rT3 / T4比值正常。在丙硫脲嘧啶给药期间，血清rT3浓度升高；在甲巯咪唑治疗期间，他们没有…
A sensitive radioimmunoassay was developed for measurement of 3,3′, 5′-triiodothyronine (rT3) in unextracted serum using 8-anilinonaphthalene- 6-sulfonic acid (ANS) to inhibit binding of rT3 to serum proteins. Normal serum r⊂ concentrations were 23 ± 8 (SD) ng/dl. Serum rT3 concentrations were elevated in patients with hyperthyroidism (90 ± 49 ng/dl), T3-hyperthyroidism (36 ± 13 ng/dl), pregnant women (49 ± 9 ng/dl) and in cord blood (280 ± 143 ng/dl). Serum rT3 concentrations were decreased in hypothyroid patients (14 ± 5 ng/dl) and fell during T3 administration to normals. In hypothyroid patients receiving T4 replacement, serum rT3 concentrations varied directly with the dose of T4 between doses of 0.050 and 0.3 mg/day. The ratio of rT3 to T4 was elevated in the sera of hypothyroid and hyperthyroid patients, but was normal in hypothyroid patients receiving T4 replacement therapy. During propylthiouracil administration, serum rT3 concentrations were elevated; during methima-zole administration they did n...