Neonatal Herpes Simplex Virus Infection
Neonatal Herpes Simplex Virus Infection
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DOI：
10.1016/j.idc.2015.05.001
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发表时间：
2015-09-01
影响因子：
4.4
通讯作者：
Kimberlin, David W.
中科院分区：
文献类型：
--
作者：
James, Scott H.;Kimberlin, David W.
单纯疱疹病毒（HSV）1和HSV-2感染在世界范围内高度流行，其特征在于建立终身感染，潜伏期穿插周期性再激活发作。婴儿在围产期或产后期间获得HSV会导致新生儿HSV疾病，这是一种罕见但重要的感染，可能与严重的发病率和死亡率相关，特别是如果存在传播或中枢神经系统受累。诊断和治疗的进步导致死亡率的改善，并在较小程度上，神经发育的结果，但仍存在进一步改善的空间。
Herpes simplex virus (HSV) 1 and HSV-2 infections are highly prevalent worldwide and are characterized by establishing lifelong infection with periods of latency interspersed with periodic episodes of reactivation. Acquisition of HSV by an infant during the peripartum or postpartum period results in neonatal HSV disease, a rare but significant infection that can be associated with severe morbidity and mortality, especially if there is dissemination or central nervous system involvement. Diagnostic and therapeutic advances have led to improvements in mortality and, to a lesser extent, neurodevelopmental outcomes, but room exists for further improvement.